Mobility and transport of pharmaceuticals nalidixic acid and niflumic acid in saturated soil columns

Luo, Tao; Chen, Tao; Boily, Jean-François; Hanna, Khalil

Abstract

Pharmaceutical compounds often coexist in mixtures rather than as individual entities. However, little is known about their co-adsorption and co-mobility in soil and groundwater. In this study, we investigated the adsorption of a quinolone antibiotic (nalidixic acid, NA) and an anti-inflammatory agent (niflumic acid, NFA) onto two soils from France and Sweden in water-saturated soil columns. Despite its lower hydrophobicity, adsorption of NA is much greater than NFA, which can be ascribed to the presence of both carbonyl and carboxylic groups in NA molecule. The data suggest that chemical adsorption to soil components can mainly take place through hydrogen bonding and surface complexation mechanisms, prevailing over hydrophobic interactions. Accordingly, more sorption of NA and NFA was observed in the Swedish soil because it contains more clay content, and much greater Al and Fe contents than the French soil. Injection of NA/NFA mixture in the column did not modify the breakthrough behavior compared to single systems, although cooperative adsorption was observed under static batch conditions. Ca2+ inhibited NA adsorption by forming a soluble NA-Ca2+ complex but promoted NFA adsorption both in single and binary systems. Their mobility in soil columns was well predicted using a new transport model that accounts for both kinetics and binding reactions of NA and NFA to soil constituents. This work will help in accurately predicting the mobility of coexisting pharmaceutical compounds in soils.

Citation

Luo, T., Chen, T., Boily, J., & Hanna, K. (2024). Mobility and transport of pharmaceuticals nalidixic acid and niflumic acid in saturated soil columns. Soil & Environmental Health, 2(1), Article 100060. https://doi.org/10.1016/j.seh.2024.100060

• Journal Article Type: Article
• Acceptance Date: Jan 16, 2024
• Online Publication Date: Jan 20, 2024
• Publication Date: 2024-02
• Deposit Date: May 20, 2024
• Publicly Available Date: May 20, 2024
• Journal: Soil & Environmental Health
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Issue: 1
• Article Number: 100060
• DOI: https://doi.org/10.1016/j.seh.2024.100060
• Public URL: https://durham-repository.worktribe.com/output/2454585