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Mitophagy in plants: Emerging regulators of mitochondrial targeting for selective autophagy

Duckney, Patrick J.; Wang, Pengwei; Hussey, Patrick J.

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Authors

Pengwei Wang



Abstract

The degradation and turnover of mitochondria is fundamental to Eukaryotes and is a key homeostatic mechanism for maintaining functional mitochondrial populations. Autophagy is an important pathway by which mitochondria are degraded, involving their sequestration into membrane‐bound autophagosomes and targeting to lytic endosomal compartments (the lysosome in animals, the vacuole in plants and yeast). Selective targeting of mitochondria for autophagy, also known as mitophagy, distinguishes mitochondria from other cell components for degradation and is necessary for the regulation of mitochondria‐specific cell processes. In mammals and yeast, mitophagy has been well characterised and is regulated by numerous pathways with diverse and important functions in the regulation of cell homeostasis, metabolism and responses to specific stresses. In contrast, we are only just beginning to understand the importance and functions of mitophagy in plants, chiefly as the proteins that target mitochondria for autophagy in plants are only recently emerging. Here, we discuss the current progress of our understanding of mitophagy in plants, the importance of mitophagy for plant life and the regulatory autophagy proteins involved in mitochondrial degradation. In particular, we will discuss the recent emergence of mitophagy receptor proteins that selectively target mitochondria for autophagy, and discuss the missing links in our knowledge of mitophagy‐regulatory proteins in plants compared to animals and yeast.

Journal Article Type Article
Acceptance Date Jan 16, 2024
Online Publication Date Jan 31, 2024
Publication Date Jan 31, 2024
Deposit Date Feb 8, 2024
Publicly Available Date Feb 8, 2024
Journal Journal of Microscopy
Print ISSN 0022-2720
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/jmi.13267
Keywords Arabidopsis, TRB1, contact site, autophagy, mitophagy, TraB, plant, mitochondria, stress, homeostasis
Public URL https://durham-repository.worktribe.com/output/2192724

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