Spatially controlled Suzuki and Heck catalytic molecular coupling.

Davis, J.J.; Bagshaw, C.B.; Busuttil, K.L.; Hanyu, Y.; Coleman, K.S.

Abstract

The initiation and control of chemical coupling has the potential to offer much within the context of “bottom up” nanofabrication. We report herein the use of a palladium-modified, catalytically active, AFM probe to initiate and spatially control surface-confined Suzuki and Heck carbon−carbon coupling reactions. These “chemically written reactions”, detectable by lateral force and chemically specific optical and topographic labeling, were patterned with line widths down to 15 nm or ∼20 molecules. Catalyzed organometallic coupling was, in this way, carried out at subzeptomolar levels. By varying the catalyst−substrate interaction times, turnover numbers of (0.6−1.2) × 104 and (3.0−5.0) × 104 molecules s-1 were resolved for Suzuki and Heck reactions, respectively.

Citation

Davis, J., Bagshaw, C., Busuttil, K., Hanyu, Y., & Coleman, K. (2006). Spatially controlled Suzuki and Heck catalytic molecular coupling. Journal of the American Chemical Society, 128(43), 14135-14141. https://doi.org/10.1021/ja064840a

• Journal Article Type: Article
• Publication Date: 2006-10
• Journal: Journal of the American Chemical Society
• Print ISSN: 0002-7863
• Electronic ISSN: 1520-5126
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 128
• Issue: 43
• Pages: 14135-14141
• DOI: https://doi.org/10.1021/ja064840a
• Public URL: https://durham-repository.worktribe.com/output/1574960