Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

Raghunath, A.; Hungin, A.P.S.; Wooff, D.; Childs, S.

Abstract

Objectives: To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease. Design: Systematic review of studies reporting the prevalence of H pylori in patients with and without gastro-oesophageal reflux disease. Data sources: Four electronic databases, searched to November 2001, experts, pharmaceutical companies, and journals. Main outcome measure: Odds ratio for prevalence of H pylori in patients with gastro-oesophageal reflux disease. Results: 20 studies were included. The pooled estimate of the odds ratio for prevalence of H pylori was 0.60 (95% confidence interval 0.47 to 0.78), indicating a lower prevalence in patients with gastro-oesophageal reflux disease. Substantial heterogeneity was observed between studies. Location seemed to be an important factor, with a much lower prevalence of H pylori in patients with gastro-oesophageal reflux disease in studies from the Far East, despite a higher overall prevalence of infection than western Europe and North America. Year of study was not a source of heterogeneity. Conclusion: The prevalence of H pylori infection was significantly lower in patients with than without gastro-oesophageal reflux, with geographical location being a strong contributor to the heterogeneity between studies. Patients from the Far East with reflux disease had a lower prevalence of H pylori infection than patients from western Europe and North America, despite a higher prevalence in the general population.

Citation

Raghunath, A., Hungin, A., Wooff, D., & Childs, S. (2003). Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. eBMJ (London), 326(7392), 737-739. https://doi.org/10.1136/bmj.326.7392.737

• Journal Article Type: Article
• Publication Date: Apr 1, 2003
• Deposit Date: May 9, 2007
• Publicly Available Date: Nov 10, 2009
• Journal: British medical journal (Clinical research edition)
• Electronic ISSN: 1468-5833
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 326
• Issue: 7392
• Pages: 737-739
• DOI: https://doi.org/10.1136/bmj.326.7392.737
• Public URL: https://durham-repository.worktribe.com/output/1567258