Catalytic, asymmetric Strecker reactions catalysed by titanium(IV) and vanadium(V)(salen) complexes.

Blacker, J.; Clutterbuck, L.A.; Crampton, M.R.; Grosjean, C.; North, M.

Abstract

VanadiumV(salen) complex 3 has been found to be an effective catalyst for the asymmetric addition of hydrogen cyanide (generated in situ from trimethylsilyl cyanide) to imines. The best results (up to 81% enantiomeric excess) were obtained for aromatic imines in which the nitrogen atom is protected with a benzyl group and in which the imine bond is not sterically encumbered.

Citation

Blacker, J., Clutterbuck, L., Crampton, M., Grosjean, C., & North, M. (2006). Catalytic, asymmetric Strecker reactions catalysed by titanium(IV) and vanadium(V)(salen) complexes. Tetrahedron: Asymmetry, 17(9), 1449-1456. https://doi.org/10.1016/j.tetasy.2006.05.015

• Journal Article Type: Article
• Publication Date: 2006
• Journal: Tetrahedron: Asymmetry
• Print ISSN: 0957-4166
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 9
• Pages: 1449-1456
• DOI: https://doi.org/10.1016/j.tetasy.2006.05.015