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A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

Battilocchio, Claudio; Deadman, Benjamin J.; Nikbin, Nikzad; Kitching, Matthew O.; Baxendale, Ian R.; Ley, Steven V.

Authors

Claudio Battilocchio

Benjamin J. Deadman

Nikzad Nikbin

Steven V. Ley



Abstract

Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.

Citation

Battilocchio, C., Deadman, B. J., Nikbin, N., Kitching, M. O., Baxendale, I. R., & Ley, S. V. (2013). A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1. Chemistry - A European Journal, 19(24), 7917-7930. https://doi.org/10.1002/chem.201300696

Journal Article Type Article
Online Publication Date Apr 16, 2013
Publication Date 2013-06
Deposit Date Jul 14, 2014
Journal Chemistry - A European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 19
Issue 24
Pages 7917-7930
DOI https://doi.org/10.1002/chem.201300696
Public URL https://durham-repository.worktribe.com/output/1448192