The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Roper, Kimberley A.; Lange, Heiko; Polyzos, Anastasios; Berry, Malcolm B.; Baxendale, Ian R.; Ley, Steven V.

Abstract

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

Citation

Roper, K. A., Lange, H., Polyzos, A., Berry, M. B., Baxendale, I. R., & Ley, S. V. (2011). The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors. Beilstein Journal of Organic Chemistry, 7, 1648-1655. https://doi.org/10.3762/bjoc.7.194

• Journal Article Type: Article
• Acceptance Date: Nov 16, 2011
• Publication Date: Dec 8, 2011
• Deposit Date: Jul 14, 2014
• Publicly Available Date: Jun 1, 2015
• Journal: Beilstein Journal of Organic Chemistry
• Print ISSN: 1860-5397
• Electronic ISSN: 1860-5397
• Publisher: Beilstein-Institut
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Pages: 1648-1655
• DOI: https://doi.org/10.3762/bjoc.7.194
• Keywords: Appel reaction, Bromination, Flow chemistry, Solid-supported reagent; triphenylphosphine monolith
• Public URL: https://durham-repository.worktribe.com/output/1448082