C.J. Mallia
Flow carbonylation of sterically hindered ortho-substituted iodoarenes
Mallia, C.J.; Walter, G.C.; Baxendale, I.R.
Abstract
The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
Citation
Mallia, C., Walter, G., & Baxendale, I. (2016). Flow carbonylation of sterically hindered ortho-substituted iodoarenes. Beilstein Journal of Organic Chemistry, 12, 1503-1511. https://doi.org/10.3762/bjoc.12.147
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 27, 2016 |
Online Publication Date | Jul 19, 2016 |
Publication Date | Jul 19, 2016 |
Deposit Date | Aug 9, 2016 |
Publicly Available Date | Aug 9, 2016 |
Journal | Beilstein Journal of Organic Chemistry |
Print ISSN | 1860-5397 |
Electronic ISSN | 1860-5397 |
Publisher | Beilstein-Institut |
Peer Reviewed | Peer Reviewed |
Volume | 12 |
Pages | 1503-1511 |
DOI | https://doi.org/10.3762/bjoc.12.147 |
Public URL | https://durham-repository.worktribe.com/output/1399423 |
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Copyright Statement
© 2016 Mallia et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
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