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Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Mallia, C.J.; Walter, G.C.; Baxendale, I.R.

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Authors

C.J. Mallia

G.C. Walter



Abstract

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.

Citation

Mallia, C., Walter, G., & Baxendale, I. (2016). Flow carbonylation of sterically hindered ortho-substituted iodoarenes. Beilstein Journal of Organic Chemistry, 12, 1503-1511. https://doi.org/10.3762/bjoc.12.147

Journal Article Type Article
Acceptance Date Jun 27, 2016
Online Publication Date Jul 19, 2016
Publication Date Jul 19, 2016
Deposit Date Aug 9, 2016
Publicly Available Date Aug 9, 2016
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 12
Pages 1503-1511
DOI https://doi.org/10.3762/bjoc.12.147

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Published Journal Article (1.1 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2016 Mallia et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)





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