Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design

Berry, David J.; Steed, Jonathan W.

Abstract

As small molecule drugs become harder to develop and less cost effective for patient use, efficient strategies for their property improvement become increasingly important to global health initiatives. Improvements in the physical properties of Active Pharmaceutical Ingredients (APIs), without changes in the covalent chemistry, have long been possible through the application of binary component solids. This was first achieved through the use of pharmaceutical salts, within the last 10–15 years with cocrystals and more recently coamorphous systems have also been consciously applied to this problem. In order to rationally discover the best multicomponent phase for drug development, intermolecular interactions need to be considered at all stages of the process. This review highlights the current thinking in this area and the state of the art in: pharmaceutical multicomponent phase design, the intermolecular interactions in these phases, the implications of these interactions on the material properties and the pharmacokinetics in a patient.

Citation

Berry, D. J., & Steed, J. W. (2017). Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design. Advanced Drug Delivery Reviews, 117, 3-24. https://doi.org/10.1016/j.addr.2017.03.003

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2017
• Online Publication Date: Mar 23, 2017
• Publication Date: Aug 1, 2017
• Deposit Date: Mar 27, 2017
• Publicly Available Date: Mar 23, 2018
• Journal: Advanced Drug Delivery Reviews
• Print ISSN: 0169-409X
• Electronic ISSN: 1872-8294
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 117
• Pages: 3-24
• DOI: https://doi.org/10.1016/j.addr.2017.03.003
• Public URL: https://durham-repository.worktribe.com/output/1390087