Marcus Baumann
Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2-carboxylate
Baumann, Marcus; Baxendale, Ian R.
Abstract
This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine and a nitrile oxide functionality. The latter reacts with an immobilized thiourea to yield an isothiocyanate which upon elimination generates the final pyrrole in an unprecedented cascade of events.
Citation
Baumann, M., & Baxendale, I. R. (2017). Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2-carboxylate. Molbank, 2017(3), Article M951. https://doi.org/10.3390/m951
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 2, 2017 |
Online Publication Date | Aug 4, 2017 |
Publication Date | Aug 4, 2017 |
Deposit Date | Aug 23, 2017 |
Publicly Available Date | Aug 23, 2017 |
Journal | Molbank |
Electronic ISSN | 1422-8599 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 2017 |
Issue | 3 |
Article Number | M951 |
DOI | https://doi.org/10.3390/m951 |
Public URL | https://durham-repository.worktribe.com/output/1378601 |
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Copyright Statement
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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