Do cortical plasticity mechanisms differ between males and females?

Dachtler, J.; Fox, K.

Abstract

The difference between male and female behavior and male and female susceptibility to a number of neuropsychiatric conditions is not controversial. From a biological perspective, one might expect to see at least some of these differences underpinned by identifiable physical differences in the brain. This Mini-Review focuses on evidence that plasticity mechanisms differ between males and females and ask at what scale of organization the differences might exist, at the systems level, the circuits level, or the synaptic level. Emerging evidence suggests that plasticity differences may extend to the scale of synaptic mechanisms. In particular, the CaMKK, NOS1 and estrogen receptor pathways show sexual dimorphisms with implications for plasticity in the hippocampus and cerebral cortex.

Citation

Dachtler, J., & Fox, K. (2017). Do cortical plasticity mechanisms differ between males and females?. Journal of Neuroscience Research, 95(1-2), 518-526. https://doi.org/10.1002/jnr.23850

• Journal Article Type: Article
• Acceptance Date: Jul 6, 2016
• Online Publication Date: Nov 7, 2016
• Publication Date: Jan 1, 2017
• Deposit Date: Nov 17, 2016
• Publicly Available Date: Nov 24, 2016
• Journal: Journal of Neuroscience Research
• Print ISSN: 0360-4012
• Electronic ISSN: 1097-4547
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 95
• Issue: 1-2
• Pages: 518-526
• DOI: https://doi.org/10.1002/jnr.23850
• Public URL: https://durham-repository.worktribe.com/output/1370137