Exploring the links between peptoid antibacterial activity and toxicity

Bolt, Hannah L.; Eggimann, Gabriela A.; Jahoda, Colin A.B.; Zuckermann, Ronald N.; Sharples, Gary J.; Cobb, Steven L.

Abstract

Peptoids are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicty data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.

Citation

Bolt, H. L., Eggimann, G. A., Jahoda, C. A., Zuckermann, R. N., Sharples, G. J., & Cobb, S. L. (2017). Exploring the links between peptoid antibacterial activity and toxicity. MedChemComm, 8(5), 886-896. https://doi.org/10.1039/c6md00648e

• Journal Article Type: Article
• Acceptance Date: Jan 22, 2017
• Online Publication Date: Feb 1, 2017
• Publication Date: May 1, 2017
• Deposit Date: Jan 30, 2017
• Publicly Available Date: Feb 9, 2017
• Journal: MedChemComm.
• Print ISSN: 2040-2503
• Electronic ISSN: 2040-2511
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 5
• Pages: 886-896
• DOI: https://doi.org/10.1039/c6md00648e
• Public URL: https://durham-repository.worktribe.com/output/1365420