Synthesis, crystal structure and DNA/protein binding of tetranuclear Cu(II) complexes with a double-open-cubane like core framework

Paul, Aparup; Puschmann, Horst; Manna, Subal Chandra

Abstract

The copper(II) complexes [Cu4(L)2(HL)2(H2O)2]∙2(ClO4)∙2(H2O)∙DMF (1) and [Cu4(L)2(HL)2(H2O)2]∙(tp) (2) [H2L = 2-ethoxy-6-[(1-hydroxymethyl-propylimino)-methyl]-phenol; tp = terephthalate] have been synthesized and characterized by single crystal X-ray diffraction and spectroscopic studies. The structural determination reveals that both the complexes are tetranuclear with a double-open-cubane like core framework. The 2D supramolecular structure of 1 and 3D supramolecular structure of 2 are formed through C-H...π and hydrogen bonding interactions, respectively. At room temperature both the complexes exhibit fluorescence with quantum yields of 0.41 and 0.40. The interactions of the complexes with calf thymus DNA (CT-DNA) and serum albumins were investigated using electronic absorption and fluorescence spectroscopic techniques. The studies revels that the binding affinities of 1 and 2 with CT-DNA are of the order 8.86×105 M-1 and 7.14×105 M-1, respectively. Additionally, the interaction of the complexes with bovine serum albumin and human serum albumin were studied and the number of binding sites and binding constants were calculated using a double logarithm regression equation. The redox activities of the complexes were investigated in methanol solution by cyclic voltammetry.

Citation

Paul, A., Puschmann, H., & Manna, S. C. (2018). Synthesis, crystal structure and DNA/protein binding of tetranuclear Cu(II) complexes with a double-open-cubane like core framework. Polyhedron, 155, 447-456. https://doi.org/10.1016/j.poly.2018.08.020

• Journal Article Type: Article
• Acceptance Date: Aug 2, 2018
• Online Publication Date: Aug 17, 2018
• Publication Date: Nov 15, 2018
• Deposit Date: Aug 20, 2018
• Publicly Available Date: Aug 17, 2019
• Journal: Polyhedron
• Print ISSN: 0277-5387
• Electronic ISSN: 1873-3719
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 155
• Pages: 447-456
• DOI: https://doi.org/10.1016/j.poly.2018.08.020
• Public URL: https://durham-repository.worktribe.com/output/1351314