Sarah J. Charman
A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care
Charman, Sarah J.; Okwose, Nduka C.; Stefanetti, Renae J.; Bailey, Kristian; Skinner, Jane; Ristic, Arsen; Seferovic, Petar M.; Scott, Mike; Turley, Stephen; Fuat, Ahmet; Mant, Jonathan; Hobbs, Richard F.D.; MacGowan, Guy A.; Jakovljevic, Djordje G.
Authors
Nduka C. Okwose
Renae J. Stefanetti
Kristian Bailey
Jane Skinner
Arsen Ristic
Petar M. Seferovic
Mike Scott
Stephen Turley
Ahmet Fuat
Jonathan Mant
Richard F.D. Hobbs
Guy A. MacGowan
Djordje G. Jakovljevic
Abstract
Aims: Primary care physicians lack access to an objective cardiac function test. This study for the first time describes a novel cardiac output response to stress (CORS) test developed to improve diagnosis and monitoring of heart failure in primary care and investigates its reproducibility. Methods and results: Prospective observational study recruited 32 consecutive primary care patients (age, 63 ± 9 years; female, n = 18). Cardiac output was measured continuously using the bioreactance method in supine and standing positions and during two 3 min stages of a step‐exercise protocol (10 and 15 steps per minute) using a 15 cm height bench. The CORS test was performed on two occasions, i.e. Test 1 and Test 2. There was no significant difference between repeated measures of cardiac output and stroke volume at supine standing and Stage 1 and Stage 2 step exercises (all P > 0.3). There was a significant positive relationship between Test 1 and Test 2 cardiac outputs (r = 0.92, P = 0.01 with coefficient of variation of 7.1%). The mean difference in cardiac output (with upper and lower limits of agreement) between Test 1 and Test 2 was 0.1 (−1.9 to 2.1) L/min, combining supine, standing, and step‐exercise data. Conclusions: The CORS, as a novel test for objective evaluation of cardiac function, demonstrates acceptable reproducibility and can potentially be implemented in primary care.
Citation
Charman, S. J., Okwose, N. C., Stefanetti, R. J., Bailey, K., Skinner, J., Ristic, A., …Jakovljevic, D. G. (2018). A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care. ESC Heart Failure, 5(4), 703-712. https://doi.org/10.1002/ehf2.12302
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 16, 2018 |
Online Publication Date | Jun 26, 2018 |
Publication Date | Aug 1, 2018 |
Deposit Date | Jun 29, 2018 |
Publicly Available Date | Jun 29, 2018 |
Journal | ESC Heart Failure |
Publisher | Wiley Open Access |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | 4 |
Pages | 703-712 |
DOI | https://doi.org/10.1002/ehf2.12302 |
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Copyright Statement
Final published version
Published Journal Article (Advance online version)
(674 Kb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
Advance online version © 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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