Ronen Blecher
New functions for the proprioceptive system in skeletal biology
Blecher, Ronen; Heinemann-Yerushalmi, Lia; Assaraf, Eran; Konstantin, Nitzan; Chapman, Jens R.; Cope, Timothy C.; Bewick, Guy S.; Banks, Robert W.; Zelzer, Elazar
Authors
Lia Heinemann-Yerushalmi
Eran Assaraf
Nitzan Konstantin
Jens R. Chapman
Timothy C. Cope
Guy S. Bewick
Robert Banks r.w.banks@durham.ac.uk
Academic Visitor
Elazar Zelzer
Abstract
Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, which appeared during peripubertal development, bears resemblance to the human condition adolescent idiopathic scoliosis. This similarity may contribute to the study of the disease by offering both an animal model and a clue as to its aetiology. Moreover, it raises the possibility that impaired proprioceptive signalling may be involved in the aetiology of other conditions. Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.
Citation
Blecher, R., Heinemann-Yerushalmi, L., Assaraf, E., Konstantin, N., Chapman, J. R., Cope, T. C., …Zelzer, E. (2018). New functions for the proprioceptive system in skeletal biology. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1759), Article 20170327. https://doi.org/10.1098/rstb.2017.0327
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 6, 2018 |
Online Publication Date | Sep 24, 2018 |
Publication Date | Sep 24, 2018 |
Deposit Date | Oct 18, 2018 |
Publicly Available Date | Oct 18, 2018 |
Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
Print ISSN | 0962-8436 |
Electronic ISSN | 1471-2970 |
Publisher | The Royal Society |
Peer Reviewed | Peer Reviewed |
Volume | 373 |
Issue | 1759 |
Article Number | 20170327 |
DOI | https://doi.org/10.1098/rstb.2017.0327 |
Public URL | https://durham-repository.worktribe.com/output/1315538 |
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(886 Kb)
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