AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance

Zhang, Liping; Li, Yuanyuan; Che, Weilong; Zhu, Dongxia; Li, Guangfu; Xie, Zhigang; Song, Nan; Liu, Shi; Tang, Ben Zhong; Liu, Xingman; Su, Zhongmin; Bryce, Martin R.

Abstract

The singlet oxygen (1O2) generation ability of a photosensitizer (PS) is pivotal for photodynamic therapy (PDT). Transition metal complexes are effective PSs, owing to their high 1O2 generation ability. However, non‐negligible cellular toxicity, poor biocompatibility, and easy aggregation in water limit their biomedical applications. In this work, a series of red‐emitting aggregation‐induced emission (AIE) Ir(III) complexes containing different numbers of Ir centers (mono‐, di‐, and trinuclear) and the corresponding nanoparticles (NPs) AIE‐NPs, are designed and synthesized. The increase of 1O2 generation ability is in line with the increasing number of Ir centers. Compared with the pure Ir(III) complexes, the corresponding NPs offer multiple advantages: (i) brighter emission; (ii) higher phosphorescence quantum yields; (iii) longer excited lifetime; (iv) higher 1O2 generation ability; (v) better biocompatibility; and (vi) superior cellular uptake. Both in vitro and in vivo experiments corroborate that AIE‐NPs with three iridium centers possess potent cytotoxicity toward cancer cells and effective inhibition of tumor growth. To the best of knowledge, this work is the first example of NPs of multinuclear AIE Ir(III) complexes as PSs for enhanced PDT. This study offers a new method to improve the efficiency of PSs for clinical cancer treatments.

Citation

Zhang, L., Li, Y., Che, W., Zhu, D., Li, G., Xie, Z., …Bryce, M. R. (2019). AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance. Advanced Science, 6(5), Article 1802050. https://doi.org/10.1002/advs.201802050

• Journal Article Type: Article
• Online Publication Date: Dec 12, 2018
• Publication Date: Mar 6, 2019
• Deposit Date: Jan 22, 2019
• Publicly Available Date: Jan 22, 2019
• Journal: Advanced Science
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 5
• Article Number: 1802050
• DOI: https://doi.org/10.1002/advs.201802050
• Public URL: https://durham-repository.worktribe.com/output/1304820