Basanta Saikia
Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide
Saikia, Basanta; Mulvee, Matthew T.; Torres-Moya, Ivan; Sarma, Bipul; Steed, Jonathan W.
Authors
Matthew T. Mulvee
Ivan Torres-Moya
Bipul Sarma
Professor Jonathan Steed jon.steed@durham.ac.uk
Professor
Abstract
A strategic approach to control the polymorphism of two related drugs by introducing a drug-mimetic imide functional group into the molecular weight organogelator structure is presented. This was achieved with novel aminoglutethimide-derived bis(urea) organogelators designed to form gels that act as targeted crystallization media for (±)-thalidomide and barbital. The organogelators prevent concomitant crystallization, a serious issue for drug formulation and development. This work demonstrates the potential to control concomitant crystallization with rationally designed supramolecular gelators.
Citation
Saikia, B., Mulvee, M. T., Torres-Moya, I., Sarma, B., & Steed, J. W. (2020). Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide. Crystal Growth and Design, 20(12), 7989-7996. https://doi.org/10.1021/acs.cgd.0c01240
Journal Article Type | Article |
---|---|
Online Publication Date | Nov 2, 2020 |
Publication Date | 2020 |
Deposit Date | Jun 3, 2021 |
Publicly Available Date | Nov 2, 2021 |
Journal | Crystal Growth and Design |
Print ISSN | 1528-7483 |
Electronic ISSN | 1528-7505 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 20 |
Issue | 12 |
Pages | 7989-7996 |
DOI | https://doi.org/10.1021/acs.cgd.0c01240 |
Public URL | https://durham-repository.worktribe.com/output/1274386 |
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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.0c01240
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