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Synthesis and characterisation of a mussel-inspired hydrogel film coating for biosensors

Millican, Jonathan M.; Bittrich, Eva; Caspari, Anja; Pöschel, Kathrin; Drechsler, Astrid; Freudenberg, Uwe; Ryan, Timothy G.; Thompson, Richard L.; Pospiech, Doris; Hutchings, Lian R.

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Jonathan M. Millican

Eva Bittrich

Anja Caspari

Kathrin Pöschel

Astrid Drechsler

Uwe Freudenberg

Timothy G. Ryan

Doris Pospiech


Mussel-inspired, catechol-containing monomers are being increasingly utilised to design versatile, adhesive, functional copolymers. This work reports the synthesis and detailed characterisation of a novel terpolymer comprising dopamine methacrylamide (DMA), in order to produce surface coatings capable of acting as biosensors for, e.g., toxins. DMA is copolymerised with 2-hydroxyethyl methacrylate (HEMA) and glycidyl methacrylate (GMA) using free radical polymerisation. The copolymers are subsequently deposited as a thin film using spin-coating. It is demonstrated that a terpolymer comprising HEMA, GMA and DMA can immobilise an IgG antibody on the film surface. The terpolymer therefore has the potential to be used as a coating in biosensing devices. It is also demonstrated that the presence of DMA impacts the copolymer properties. In-situ ellipsometry is used to confirm the important role of the catechol group on copolymer adhesion and significant desorption was observed in the absence of DMA.

Journal Article Type Article
Acceptance Date May 3, 2021
Online Publication Date May 6, 2021
Publication Date 2021-06
Deposit Date May 19, 2021
Publicly Available Date May 6, 2023
Journal European Polymer Journal
Print ISSN 0014-3057
Electronic ISSN 1873-1945
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 153
Article Number 110503
Public URL


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