Lydia Costello
Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro
Costello, Lydia; Dicolandrea, Teresa; Tasseff, Ryan; Isfort, Robert; Bascom, Charlie; von Zglinicki, Thomas; Przyborski, Stefan
Authors
Teresa Dicolandrea
Ryan Tasseff
Robert Isfort
Charlie Bascom
Thomas von Zglinicki
Professor Stefan Przyborski stefan.przyborski@durham.ac.uk
Deputy Provost
Abstract
Human skin ageing is a complex and heterogeneous process, which is influenced by genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic stressors. In the current world ageing demographic, there is a requirement for a bioengineered ageing skin model, to further the understanding of the intricate molecular mechanisms of skin ageing, and provide a distinct and biologically relevant platform for testing actives and formulations. There have been many recent advances in the development of skin models that recapitulate aspects of the ageing phenotype in vitro. This review encompasses the features of skin ageing, the molecular mechanisms that drive the ageing phenotype, and tissue engineering strategies that have been utilised to bioengineer ageing skin in vitro.
Citation
Costello, L., Dicolandrea, T., Tasseff, R., Isfort, R., Bascom, C., von Zglinicki, T., & Przyborski, S. (2022). Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro. Aging Cell, 21(2), Article e13550. https://doi.org/10.1111/acel.13550
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 29, 2021 |
Online Publication Date | Jan 17, 2022 |
Publication Date | Feb 14, 2022 |
Deposit Date | Jan 18, 2022 |
Publicly Available Date | Jan 18, 2022 |
Journal | Aging Cell |
Print ISSN | 1474-9718 |
Electronic ISSN | 1474-9726 |
Publisher | Anatomical Society of Great Britain and Ireland |
Peer Reviewed | Peer Reviewed |
Volume | 21 |
Issue | 2 |
Article Number | e13550 |
DOI | https://doi.org/10.1111/acel.13550 |
Public URL | https://durham-repository.worktribe.com/output/1219779 |
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Copyright Statement
Early View © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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