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Membrane contact sites and cytoskeleton-membrane interactions in autophagy

Duckney, Patrick J.; Wang, Pengwei; Hussey, Patrick J.

Membrane contact sites and cytoskeleton-membrane interactions in autophagy Thumbnail


Authors

Pengwei Wang



Abstract

In Eukaryotes, organelle interactions occur at specialised contact sites between organelle membranes. Contact sites are regulated by specialised tethering proteins, which bring organelle membranes into close proximity, and facilitate functional crosstalk between compartments. Whilst contact site proteins are well characterised in mammals and yeast, the regulators of plant contact site formation are only now beginning to emerge. Having unique subcellular structures, plants must also utilise unique mechanisms of organelle interaction to regulate plant-specific functions. The recently characterised NETWORKED proteins are the first dedicated family of plant-specific contact site proteins. Research into the NET proteins and their interacting partners continues to uncover plantspecific mechanisms of organelle interaction and the importance of these organelle contacts to plant life. Moreover, it is becoming increasingly apparent that organelle interactions are fundamental to autophagy in plants. Here, we will present recent developments in our understanding of the mechanisms of plant organelle interactions, their functions, and emerging roles in autophagy.

Citation

Duckney, P. J., Wang, P., & Hussey, P. J. (2022). Membrane contact sites and cytoskeleton-membrane interactions in autophagy. FEBS Letters, 596(17), 2093-2103. https://doi.org/10.1002/1873-3468.14414

Journal Article Type Article
Acceptance Date May 12, 2022
Online Publication Date Jun 1, 2022
Publication Date 2022-09
Deposit Date Jul 18, 2022
Publicly Available Date Feb 7, 2023
Journal FEBS Letters
Print ISSN 0014-5793
Publisher Federation of European Biochemical Societies
Peer Reviewed Peer Reviewed
Volume 596
Issue 17
Pages 2093-2103
DOI https://doi.org/10.1002/1873-3468.14414
Public URL https://durham-repository.worktribe.com/output/1197430

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.






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