Juanita Gutiérrez-Valencia
Genomic analyses of the Linum distyly supergene reveal convergent evolution at the molecular level
Gutiérrez-Valencia, Juanita; Fracassetti, Marco; Berdan, Emma L.; Bunikis, Ignas; Soler, Lucile; Dainat, Jacques; Kutschera, Verena E.; Losvik, Aleksandra; Désamoré, Aurélie; Hughes, P. William; Foroozani, Alireza; Laenen, Benjamin; Pesquet, Edouard; Abdelaziz, Mohamed; Pettersson, Olga Vinnere; Nystedt, Björn; Brennan, Adrian C.; Arroyo, Juan; Slotte, Tanja
Authors
Marco Fracassetti
Emma L. Berdan
Ignas Bunikis
Lucile Soler
Jacques Dainat
Verena E. Kutschera
Aleksandra Losvik
Aurélie Désamoré
P. William Hughes
Alireza Foroozani
Benjamin Laenen
Edouard Pesquet
Mohamed Abdelaziz
Olga Vinnere Pettersson
Björn Nystedt
Dr Adrian Brennan a.c.brennan@durham.ac.uk
Associate Professor
Juan Arroyo
Tanja Slotte
Abstract
Supergenes govern multi-trait-balanced polymorphisms in a wide range of systems; however, our understanding of their origins and evolution remains incomplete. The reciprocal placement of stigmas and anthers in pin and thrum floral morphs of distylous species constitutes an iconic example of a balanced polymorphism governed by a supergene, the distyly S-locus. Recent studies have shown that the Primula and Turnera distyly supergenes are both hemizygous in thrums, but it remains unknown whether hemizygosity is pervasive among distyly S-loci. As hemizygosity has major consequences for supergene evolution and loss, clarifying whether this genetic architecture is shared among distylous species is critical. Here, we have characterized the genetic architecture and evolution of the distyly supergene in Linum by generating a chromosome-level genome assembly of Linum tenue, followed by the identification of the S-locus using population genomic data. We show that hemizygosity and thrum-specific expression of S-linked genes, including a pistil-expressed candidate gene for style length, are major features of the Linum S-locus. Structural variation is likely instrumental for recombination suppression, and although the non-recombining dominant haplotype has accumulated transposable elements, S-linked genes are not under relaxed purifying selection. Our findings reveal remarkable convergence in the genetic architecture and evolution of independently derived distyly supergenes, provide a counterexample to classic inversion-based supergenes, and shed new light on the origin and maintenance of an iconic floral polymorphism.
Citation
Gutiérrez-Valencia, J., Fracassetti, M., Berdan, E. L., Bunikis, I., Soler, L., Dainat, J., Kutschera, V. E., Losvik, A., Désamoré, A., Hughes, P. W., Foroozani, A., Laenen, B., Pesquet, E., Abdelaziz, M., Pettersson, O. V., Nystedt, B., Brennan, A. C., Arroyo, J., & Slotte, T. (2022). Genomic analyses of the Linum distyly supergene reveal convergent evolution at the molecular level. Current Biology, 32(20), 4360-4371. https://doi.org/10.1016/j.cub.2022.08.042
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 15, 2022 |
Online Publication Date | Sep 9, 2022 |
Publication Date | Oct 24, 2022 |
Deposit Date | Oct 12, 2022 |
Publicly Available Date | Mar 21, 2023 |
Journal | Current Biology |
Print ISSN | 0960-9822 |
Publisher | Cell Press |
Peer Reviewed | Peer Reviewed |
Volume | 32 |
Issue | 20 |
Article Number | E6 |
Pages | 4360-4371 |
DOI | https://doi.org/10.1016/j.cub.2022.08.042 |
Public URL | https://durham-repository.worktribe.com/output/1189073 |
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Copyright Statement
© 2022 The Author(s). Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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