The effect of magnetic resonance imaging on mercury release from dental amalgam at 3T and 7T

Allison, James R.; Chary, Karthik; Ottley, Chris; Vuong, Quoc C.; German, Matthew J.; Durham, Justin; Thelwall, Peter

Abstract

Objectives To measure mercury release from standardised hydroxyapatite/amalgam constructs during MRI scanning and investigate the impact of static field strength and radiofrequency (RF) power on mercury release. Methods Amalgam was placed into 140 hydroxyapatite disks and matured for 14-days in artificial saliva. The solution was replaced, and samples split into five groups of 28 immediately prior to MRI. One group had no exposure, and the remainder were exposed to either a 3T or 7T MRI scanner, each at high and low RF power. Mercury concentration was measured by inductively coupled plasma mass spectrometry. Groups were compared using one-way ANOVA, and two-way ANOVA for main effects/ interaction of field strength/ RF power. Results Mercury concentration was increased in the 7T groups (high/ low: 15.43/ 11.33 ng mL−1) and 3T high group (3.59) compared to control (2.44). MRI field strength significantly increased mercury release (p < .001) as did RF power (p = .030). At 3T, mercury release was 20.3 times lower than during maturation of dental amalgam, and for the average person an estimated 1.50 ng kg−1 of mercury might be released during one 3T investigation; this is substantially lower than the tolerable weekly intake of 4,000 ng kg−1. Conclusion Mercury release from amalgam shows a measurable increase following MRI, and the magnitude changes with magnetic field strength and RF power. The amount of mercury released is small compared to release during amalgam maturation. Amalgam mercury release during MRI is unlikely to be clinically meaningful and highly likely to remain below safe levels.

Citation

Allison, J. R., Chary, K., Ottley, C., Vuong, Q. C., German, M. J., Durham, J., & Thelwall, P. (2022). The effect of magnetic resonance imaging on mercury release from dental amalgam at 3T and 7T. Journal of Dentistry, 127, Article 104322. https://doi.org/10.1016/j.jdent.2022.104322

• Journal Article Type: Article
• Acceptance Date: Oct 9, 2022
• Online Publication Date: Oct 14, 2022
• Publication Date: 2022
• Deposit Date: Jan 30, 2023
• Publicly Available Date: Jan 30, 2023
• Journal: Journal of Dentistry
• Print ISSN: 0300-5712
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 127
• Article Number: 104322
• DOI: https://doi.org/10.1016/j.jdent.2022.104322
• Public URL: https://durham-repository.worktribe.com/output/1183933