Outputs (185)

A transcriptomic time-series reveals differing trajectories during pre-floral development in the apex and leaf in winter and spring varieties of Brassica napus (2024)
Journal Article
Jones, D. M., Hepworth, J., Wells, R., Pullen, N., Trick, M., & Morris, R. J. (2024). A transcriptomic time-series reveals differing trajectories during pre-floral development in the apex and leaf in winter and spring varieties of Brassica napus. Scientific Reports, 14(1), Article 3538. https://doi.org/10.1038/s41598-024-53526-x

Oilseed rape (Brassica napus) is an important global oil crop, with spring and winter varieties grown commercially. To understand the transcriptomic differences between these varieties, we collected transcriptomes from apex and leaf tissue from a spr... Read More about A transcriptomic time-series reveals differing trajectories during pre-floral development in the apex and leaf in winter and spring varieties of Brassica napus.

An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease (2024)
Journal Article
Mobbs, C. L., Darling, N. J., & Przyborski, S. (2024). An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease. Frontiers in Immunology, 15, Article 1357690. https://doi.org/10.3389/fimmu.2024.1357690

At present, preclinical models of inflammatory bowel disease (IBD) are insufficient, limiting translation between research and new therapeutics. This is especially true for fistulising Crohn’s disease (CD), as the severe lack of relevant models hinde... Read More about An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease.

Continent-wide differences in diet breadth of large terrestrial carnivores: the effect of large prey and competitors (2024)
Journal Article
Stephens, P. (2024). Continent-wide differences in diet breadth of large terrestrial carnivores: the effect of large prey and competitors. Mammal Review, 54(3), 288-298. https://doi.org/10.1111/mam.12343

Despite their importance for understanding consumer-resource dynamics, the dietary responses of large terrestrial predators to variations in prey richness and competition pressure are unclear. While a greater predator selectivity along with increasin... Read More about Continent-wide differences in diet breadth of large terrestrial carnivores: the effect of large prey and competitors.

Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads (2024)
Journal Article
Agostino, V. S., Buerdsell, M. L., Uliana, S. R. B., Denny, P. W., Coelho, A. C., & Steel, P. G. (2024). Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads. Organic and Biomolecular Chemistry, 22(9), 1812-1820. https://doi.org/10.1039/d3ob02091f

A library of hybrid molecules is developed based on the common chemical features shared by clemastine and tamoxifen both of which are well known for their antileishmanial activities. In the initial screening against Leishmania major and L. amazonensi... Read More about Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads.

Mutualisms drive plant trait evolution beyond interaction‐related traits (2024)
Journal Article
Burin, G., Campbell, L. C. E., Renner, S. S., Kiers, E. T., & Chomicki, G. (2024). Mutualisms drive plant trait evolution beyond interaction‐related traits. Ecology Letters, 27(2), Article e14379. https://doi.org/10.1111/ele.14379

Mutualisms have driven the evolution of extraordinary structures and behavioural traits, but their impact on traits beyond those directly involved in the interaction remains unclear. We addressed this gap using a highly evolutionarily replicated syst... Read More about Mutualisms drive plant trait evolution beyond interaction‐related traits.

Running rings around protein cages: a case study of artificial TRAP cages (2024)
Book Chapter
Gaweł, S., Naskalska, A., Osiński, N., & Gardiner Heddle, J. (2024). Running rings around protein cages: a case study of artificial TRAP cages. In M. Ryadnov, & K. Matsuura (Eds.), Amino Acids, Peptides and Proteins: Volume 45 (45-63). Royal Society of Chemistry. https://doi.org/10.1039/bk9781839169328-00045

Proteins that constitute the capsids of viruses are well known for their ability to assemble into cage-like containers. Such containers can carry out useful tasks such as the delivery of cargoes to cells. Here we briefly review our work on naturally-... Read More about Running rings around protein cages: a case study of artificial TRAP cages.

Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species (2024)
Journal Article
Ridgway, A. M., Hood, E. J., Jimenez, J. F., Nunes, M. D., & McGregor, A. P. (2024). Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species. Current Biology, 34(5), 1114-1121. https://doi.org/10.1016/j.cub.2024.01.022

The emergence and diversification of morphological novelties is a major feature of animal evolution. However, relatively little is known about the genetic basis of the evolution of novel structures and the mechanisms underlying their diversification... Read More about Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species.

Diabetes Mellitus and Pregnancy: An Insight into the Effects on the Epigenome (2024)
Journal Article
Meza-León, A., Montoya-Estrada, A., Reyes-Muñoz, E., & Romo-Yáñez, J. (2024). Diabetes Mellitus and Pregnancy: An Insight into the Effects on the Epigenome. Biomedicines, 12(2), Article 351. https://doi.org/10.3390/biomedicines12020351

Worldwide, diabetes mellitus represents a growing health problem. If it occurs during pregnancy, it can increase the risk of various abnormalities in early and advanced life stages of exposed individuals due to fetal programming occurring in utero. S... Read More about Diabetes Mellitus and Pregnancy: An Insight into the Effects on the Epigenome.

Mitophagy in plants: Emerging regulators of mitochondrial targeting for selective autophagy (2024)
Journal Article
Duckney, P. J., Wang, P., & Hussey, P. J. (2025). Mitophagy in plants: Emerging regulators of mitochondrial targeting for selective autophagy. Journal of Microscopy, 297(3), 325-332. https://doi.org/10.1111/jmi.13267

The degradation and turnover of mitochondria is fundamental to Eukaryotes and is a key homeostatic mechanism for maintaining functional mitochondrial populations. Autophagy is an important pathway by which mitochondria are degraded, involving their s... Read More about Mitophagy in plants: Emerging regulators of mitochondrial targeting for selective autophagy.

The Oncogenic Lipid Sphingosine-1-Phosphate Impedes the Phagocytosis of Tumor Cells by M1 Macrophages in Diffuse Large B Cell Lymphoma (2024)
Journal Article
Perry, T. A., Masand, N., Vrzalikova, K., Pugh, M., Wei, W., Hollows, R., …Murray, P. G. (2024). The Oncogenic Lipid Sphingosine-1-Phosphate Impedes the Phagocytosis of Tumor Cells by M1 Macrophages in Diffuse Large B Cell Lymphoma. Cancers, 16(3), Article 574. https://doi.org/10.3390/cancers16030574

Simple Summary: Diffuse large B cell lymphoma (DLBCL), the most common form of non-Hodgkin lymphoma, is clinically aggressive and associated with poor patient outcomes. Antagonists of the small oncogenic lipid sphingosine-1-phosphate (S1P) are alread... Read More about The Oncogenic Lipid Sphingosine-1-Phosphate Impedes the Phagocytosis of Tumor Cells by M1 Macrophages in Diffuse Large B Cell Lymphoma.