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Outputs (185)

TREATMENT OF LEISHMANIASIS (2024)
Patent
Denny, P., Steel, P., & Lyne, V. (2024). TREATMENT OF LEISHMANIASIS. WO 2024/084186 A1

The invention relates to compounds of formula (I), which may be used in the treatment of microbial infections. In particular, compounds of formula (I) are effective at treating leishmaniasis. The invention extends to novel compositions, therapies and... Read More about TREATMENT OF LEISHMANIASIS.

Carotenoid skin ornaments as flexible indicators of male foraging behavior in a marine predator: Variation among Mexican colonies of brown booby ( Sula leucogaster ) (2024)
Journal Article
Michael, N. P., Torres, R., Welch, A. J., Felis, J., Adams, J., Bonillas-Monge, M. E., …Wiley, A. E. (2024). Carotenoid skin ornaments as flexible indicators of male foraging behavior in a marine predator: Variation among Mexican colonies of brown booby ( Sula leucogaster ). Marine Biology, 171(5), Article 118. https://doi.org/10.1007/s00227-024-04429-y

Carotenoid-dependent ornaments can reflect animals’ diet and foraging behaviors. However, this association should be spatially flexible and variable among populations to account for geographic variation in optimal foraging behaviors. We tested this h... Read More about Carotenoid skin ornaments as flexible indicators of male foraging behavior in a marine predator: Variation among Mexican colonies of brown booby ( Sula leucogaster ).

Dependence of nucleosome mechanical stability on DNA mismatches (2024)
Journal Article
Ngo, T. T., Liu, B., Wang, F., Basu, A., Wu, C., & Ha, T. (2024). Dependence of nucleosome mechanical stability on DNA mismatches. eLife, 13, Article RP95514. https://doi.org/10.7554/elife.95514

The organization of nucleosomes into chromatin and their accessibility are shaped by local DNA mechanics. Conversely, nucleosome positions shape genetic variations, which may originate from mismatches during replication and chemical modification of D... Read More about Dependence of nucleosome mechanical stability on DNA mismatches.

SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana. (2024)
Journal Article
Sureshkumar, S., Bandaranayake, C., Lv, J., Dent, C. I., Bhagat, P. K., Mukherjee, S., …Balasubramanian, S. (2024). SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana. Nature Plants, 10, 749-759. https://doi.org/10.1038/s41477-024-01672-5

Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich's ataxia in humans. The molecular mechanisms underlying repeat expansion-induced ep... Read More about SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana..

Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection (2024)
Journal Article
De Los Santos Gomez, P., Costello, L., Goncalves, K., & Przyborski, S. (2024). Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection. Frontiers in Medicine, 11, Article 1355799. https://doi.org/10.3389/fmed.2024.1355799

Introduction: Daily solar ultraviolet (UV) radiation has an important impact on skin health. Understanding the initial events of the UV-induced response is critical to prevent deleterious conditions. However, studies in human volunteers have ethical,... Read More about Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection.

Structure ofEscherichia coliDNA gyrase with chirally wrapped DNA supports ratchet-and-pawl mechanism for an ATP-powered supercoiling motor (2024)
Preprint / Working Paper
Michalczyk, E., Pabiś, M., Heddle, J., & Ghilarov, D. (in press). Structure ofEscherichia coliDNA gyrase with chirally wrapped DNA supports ratchet-and-pawl mechanism for an ATP-powered supercoiling motor

Gyrase is essential for replication and transcription in bacteria, and as such is an important target for antibiotics including fluoroquinolones. Gyrase is a molecular machine that channels the energy of ATP hydrolysis into negative supercoiling of D... Read More about Structure ofEscherichia coliDNA gyrase with chirally wrapped DNA supports ratchet-and-pawl mechanism for an ATP-powered supercoiling motor.

PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. (2024)
Journal Article
Atkinson, R., Georgiou, M., Yang, C., Szymanska, K., Lahat, A., Vasconcelos, E. J. R., …Lako, M. (2024). PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature Communications, 15(1), Article 3138. https://doi.org/10.1038/s41467-024-47253-0

The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism. We used patient indu... Read More about PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects..

Evaluating the performance of key ERA‐Interim, ERA5 and ERA5‐Land climate variables across Siberia (2024)
Journal Article
Baxter, R., Clelland, A., & Marshall, G. (2024). Evaluating the performance of key ERA‐Interim, ERA5 and ERA5‐Land climate variables across Siberia. International Journal of Climatology, 44(7), 2318-2342. https://doi.org/10.1002/joc.8456

Reanalysis datasets provide a continuous picture of the past climate for every point on Earth. They are especially useful in areas with few direct observations, such as Siberia. However, to ensure these datasets are sufficiently accurate they need to... Read More about Evaluating the performance of key ERA‐Interim, ERA5 and ERA5‐Land climate variables across Siberia.

Looking across the gap: Understanding the evolution of eyes and vision among insects (2024)
Journal Article
Kittelmann, M., & McGregor, A. P. (2024). Looking across the gap: Understanding the evolution of eyes and vision among insects. BioEssays, 46(5), Article 2300240. https://doi.org/10.1002/bies.202300240

The compound eyes of insects exhibit stunning variation in size, structure, and function, which has allowed these animals to use their vision to adapt to a huge range of different environments and lifestyles, and evolve complex behaviors. Much of our... Read More about Looking across the gap: Understanding the evolution of eyes and vision among insects.