Outputs (3467)

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. (2006)
Journal Article
Pan, P., Curtis, F., Carroll, C., Medina, I., Rodrigeuz, R., Liotta, L., …McAlpine, S. (2006). Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. Bioorganic and Medicinal Chemistry, 14(14), 4731-4739. https://doi.org/10.1016/j.bmc.2006.03.028

Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell deat... Read More about Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC..

Lamina-associated polypeptide 2 alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway (2006)
Journal Article
Dorner, D., Vlcek, S., Foeger, N., Gajewski, A., Makolm, C., Gotzmann, J., …Foisner, R. (2006). Lamina-associated polypeptide 2 alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. Journal of Cell Biology, 173(1), 83-93. https://doi.org/10.1083/jcb.200511149

Lamina-associated polypeptide (LAP) 2 is a nonmembrane-bound LAP2 isoform that forms complexes with nucleoplasmic A-type lamins. In this study, we show that the overexpression of LAP2 in fibroblasts reduced proliferation and delayed entry into the ce... Read More about Lamina-associated polypeptide 2 alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway.

Oligomerization of recombinant and endogenously expressed human histamine H4 receptors (2006)
Journal Article
Van Rijn, R., Chazot, P., Shenton, F., Sansuk, K., Bakker, R., & Leurs, R. (2006). Oligomerization of recombinant and endogenously expressed human histamine H4 receptors. Molecular Pharmacology, 70(2), 604-615. https://doi.org/10.1124/mol.105.020818

In this study, we report the homo- and hetero-oligomerization of the human histamine H4R by both biochemical (Western blot and immobilized metal affinity chromatography) and biophysical [bioluminescence resonance energy transfer and time-resolved flu... Read More about Oligomerization of recombinant and endogenously expressed human histamine H4 receptors.

Dissipation and maintenance of stable states in an enzymatic system: Analysis and simulation (2006)
Journal Article
Liu, J. (2006). Dissipation and maintenance of stable states in an enzymatic system: Analysis and simulation. Biophysical Chemistry, 120(3), 207-214. https://doi.org/10.1016/j.bpc.2005.11.011

The constraint-based analysis has emerged as a useful tool for analysis of biochemical networks. An essential assumption for constraint-based analysis is the formation of a stable steady state. This work investigates dissipation and maintenance of st... Read More about Dissipation and maintenance of stable states in an enzymatic system: Analysis and simulation.

Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cell lines (2006)
Journal Article
Saleki, K., Hartigan, N., van Lith, M., Bulleid, N., & Benham, A. (2006). Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cell lines. Antioxidants and Redox Signaling, 8(3-4), 292-299. https://doi.org/10.1089/ars.2006.8.292

MHC class I molecules are predominantly involved in the presentation of antigens from viral proteins to CD8+ T cells of the immune system. However, MHC proteins can also be linked to autoimmune diseases, and the HLA-B27 allele is expressed by 95% of... Read More about Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cell lines.

Perceived nuisance of mosquitoes on the Isle of Sheppey, Kent, UK. (2006)
Journal Article
Hutchinson, R., & Lindsay, S. (2006). Perceived nuisance of mosquitoes on the Isle of Sheppey, Kent, UK. Journal of Biosocial Science, 38(5), 707-712. https://doi.org/10.1017/s0021932005000994

Little is known about the biting nuisance of mosquitoes in the UK, despite the high numbers found in some locations. A telephone questionnaire survey was used to determine the perceived nuisance of biting insects on the Isle of Sheppey, Kent, a place... Read More about Perceived nuisance of mosquitoes on the Isle of Sheppey, Kent, UK..

Relationship between the intensity of exposure to malaria parasites and infection in the Usambara mountains, Tanzania (2006)
Journal Article
Bodker, R., Msangeni, H., Kisinza, W., & Lindsay, S. (2006). Relationship between the intensity of exposure to malaria parasites and infection in the Usambara mountains, Tanzania. American Journal of Tropical Medicine and Hygiene, 74(5), 716-723. https://doi.org/10.4269/ajtmh.2006.74.716

The relationship between exposure to Plasmodium falciparum malaria and parasite density and prevalence was studied in six communities along an altitude transect. Prevalence of parasitemia in children decreased by 5% for every 100 meter increase in al... Read More about Relationship between the intensity of exposure to malaria parasites and infection in the Usambara mountains, Tanzania.

Tandem affinity purification tagging of fatty acid biosynthetic enzymesin Synechocystis sp PCC6803 and Arabidopsis thaliana (2006)
Journal Article
Brown, A. P., Affleck, V., Fawcett, T., & Slabas, A. R. (2006). Tandem affinity purification tagging of fatty acid biosynthetic enzymesin Synechocystis sp PCC6803 and Arabidopsis thaliana. Journal of Experimental Botany, 57(7), 1563-1571. https://doi.org/10.1093/jxb/erj150

De novo fatty acid synthesis in plants occurs primarily in the plastids and is catalysed by a type-II fatty acid synthase (FAS) in which separate enzymes catalyse sequential reactions. Genes encoding all of the plant FAS components have been identifi... Read More about Tandem affinity purification tagging of fatty acid biosynthetic enzymesin Synechocystis sp PCC6803 and Arabidopsis thaliana.

Influence of slope and aspect on long-term vegetation change in British chalk grasslands (2006)
Journal Article
Bennie, J., Hill, M. O., Baxter, R., & Huntley, B. (2006). Influence of slope and aspect on long-term vegetation change in British chalk grasslands. Journal of Ecology, 94(2), 355-368. https://doi.org/10.1111/j.1365-2745.2006.01104.x

1 The species composition of fragmented semi-natural grasslands may change over time due to stochastic local extinction and colonization events, successional change and/or as a response to changing management or abiotic conditions. The resistance of... Read More about Influence of slope and aspect on long-term vegetation change in British chalk grasslands.

Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance (2006)
Journal Article
Touil, F., Pratt, S., Mutter, R., & Chen, B. (2006). Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance. Journal of Pharmaceutical and Biomedical Analysis, 40(3), 822-832. https://doi.org/10.1016/j.jpba.2005.08.011

The conversion of cellular prion protein (PrPC) to the protease resistant isoform (PrPSc) is considered essential for the progression of transmissible spongiform encephalopathies (TSEs). A potential therapeutic strategy for preventing the accumulatio... Read More about Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance.