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Outputs (3)

Multiple carbamylation events are required for differential modulation of Cx26 hemichannels and gap junctions by CO 2 (2025)
Journal Article
Nijjar, S., Brotherton, D., Butler, J., Dospinescu, V., Gannon, H. G., Linthwaite, V., Cann, M., Cameron, A., & Dale, N. (online). Multiple carbamylation events are required for differential modulation of Cx26 hemichannels and gap junctions by CO 2. The Journal of Physiology, https://doi.org/10.1113/jp285885

CO2 directly modifies the gating of connexin26 (Cx26) gap junction channels and hemichannels. This gating depends upon Lys125, and the proposed mechanism involves carbamylation of Lys125 to allow formation of a salt bridge with Arg104 on the neighbou... Read More about Multiple carbamylation events are required for differential modulation of Cx26 hemichannels and gap junctions by CO 2.

Ubiquitin is a carbon dioxide-binding protein (2021)
Journal Article
Linthwaite, V., Pawloski, W., Pegg, H., Townsend, P., Thomas, M., Brown, A., Hodgson, D., Lorimer, G., Fushman, D., & Cann, M. (2021). Ubiquitin is a carbon dioxide-binding protein. Science Advances, 7(39), Article eabi5507. https://doi.org/10.1126/sciadv.abi5507

The identification of CO2-binding proteins is crucial to understanding CO2-regulated molecular processes. CO2 can form a reversible posttranslational modification through carbamylation of neutral N-terminal -amino or lysine -amino groups. We have p... Read More about Ubiquitin is a carbon dioxide-binding protein.

A methodology for carbamate post-translational modification discovery and its application in Escherichia coli (2021)
Journal Article
Linthwaite, V. L., & Cann, M. J. (2021). A methodology for carbamate post-translational modification discovery and its application in Escherichia coli. Interface Focus, 11(2), Article 20200028. https://doi.org/10.1098/rsfs.2020.0028

Carbon dioxide can influence cell phenotypes through the modulation of signalling pathways. CO2 regulates cellular processes as diverse as metabolism, cellular homeostasis, chemosensing and pathogenesis. This diversity of regulated processes suggests... Read More about A methodology for carbamate post-translational modification discovery and its application in Escherichia coli.