Outputs (14)

Molecular basis of tRNA recognition by the Elongator complex (2019)
Journal Article
Dauden, M. I., Jaciuk, M., Weis, F., Lin, T., Kleindienst, C., Abbassi, N. E. H., …Glatt, S. (2019). Molecular basis of tRNA recognition by the Elongator complex. Science Advances, 5(7), https://doi.org/10.1126/sciadv.aaw2326

The highly conserved Elongator complex modifies transfer RNAs (tRNAs) in their wobble base position, thereby regulating protein synthesis and ensuring proteome stability. The precise mechanisms of tRNA recognition and its modification reaction remain... Read More about Molecular basis of tRNA recognition by the Elongator complex.

The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase (2019)
Journal Article
Lin, T., Abbassi, N. E. H., Zakrzewski, K., Chramiec-Głąbik, A., Jemioła-Rzemińska, M., Różycki, J., & Glatt, S. (2019). The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase. Nature Communications, 10(1), https://doi.org/10.1038/s41467-019-08579-2

The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching carboxy-methyl (cm5) moieties to uridine bases located in the wobble position. The catalytic subunit Elp3 is highly conserved and harbors two individual subdomains, a... Read More about The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase.

Liquid Crystalline Granules Align in a Hierarchical Structure To Produce Spider Dragline Microfibrils (2017)
Journal Article
Lin, T., Masunaga, H., Sato, R., Malay, A. D., Toyooka, K., Hikima, T., & Numata, K. (2017). Liquid Crystalline Granules Align in a Hierarchical Structure To Produce Spider Dragline Microfibrils. Biomacromolecules, 18(4), 1350-1355. https://doi.org/10.1021/acs.biomac.7b00086

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi (2016)
Journal Article
Glatt, S., Zabel, R., Kolaj-Robin, O., Onuma, O. F., Baudin, F., Graziadei, A., …Müller, C. W. (2016). Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi. Nature Structural and Molecular Biology, 23(9), 794-802. https://doi.org/10.1038/nsmb.3265

During translation elongation, decoding is based on the recognition of codons by corresponding tRNA anticodon triplets. Molecular mechanisms that regulate global protein synthesis via specific base modifications in tRNA anticodons are receiving incre... Read More about Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.