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Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents (2006)
Journal Article
Cope, H., Mutter, R., Heal, W., Pascoe, C., Brown, P., Pratt, S., & Chen, B. (2006). Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents. European Journal of Medicinal Chemistry, 41(10), 1124-1143. https://doi.org/10.1016/j.ejmech.2006.05.002

Transmissible spongiform encephalopathies (TSEs) are thought to arise from aggregation of a protease resistant protein denoted PrPSc, which is a misfolded isoform of the normal cellular prion protein PrPC. Using virtual high-throughput screening we h... Read More about Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents.

Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity (2006)
Journal Article
Gottschalg, E., Moore, N., Ryan, A., Travis, L., Waller, R., Pratt, S., …Fry, J. (2006). Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity. Chemico-Biological Interactions: A journal of molecular, cellular and biochemical toxicology, 161(3), 251-261. https://doi.org/10.1016/j.cbi.2006.04.003

Exposure of cells to toxic chemicals is known to up-regulate the expression of a number of stress proteins (SPs), including metallothionein (MT) and members of the heat shock protein (HSP) family, and this response may allow the development of a fing... Read More about Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity.

Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance (2006)
Journal Article
Touil, F., Pratt, S., Mutter, R., & Chen, B. (2006). Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance. Journal of Pharmaceutical and Biomedical Analysis, 40(3), 822-832. https://doi.org/10.1016/j.jpba.2005.08.011

The conversion of cellular prion protein (PrPC) to the protease resistant isoform (PrPSc) is considered essential for the progression of transmissible spongiform encephalopathies (TSEs). A potential therapeutic strategy for preventing the accumulatio... Read More about Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance.

Library Design, Synthesis And Screening: Pyridine Dicarbonitriles As Potential Prion Disease Therapeutics (2006)
Journal Article
Reddy, T., Mutter, R., Heal, W., Guo, K., Pratt, S., Gillet, V., & Chen, B. (2006). Library Design, Synthesis And Screening: Pyridine Dicarbonitriles As Potential Prion Disease Therapeutics. Journal of Medicinal Chemistry, 49(2), 607-615. https://doi.org/10.1021/jm050610f

Transmissible spongiform encephalopathies (TSEs) or prion diseases are a family of invariably fatal neurodegenerative disorders, and there are no effective therapeutics currently available. In this paper, we report on the design, synthesis, and scree... Read More about Library Design, Synthesis And Screening: Pyridine Dicarbonitriles As Potential Prion Disease Therapeutics.

Increased Heat Shock Protein 70 Expression Following Toxicant-Mediated Cytotoxicity: A Ubiquitous Marker Of Toxicant Exposure? (2005)
Journal Article
Farzaneh, P., Allameh, A., Pratt, S., Moore, N., Travis, L., Gottschalg, E., …Fry, J. (2005). Increased Heat Shock Protein 70 Expression Following Toxicant-Mediated Cytotoxicity: A Ubiquitous Marker Of Toxicant Exposure?. Alternatives to Laboratory Animals, 33(2), 105-110

The up-regulation of heat shock protein (HSP) expression has been proposed as a general biomarker of cellular protection against various environmental stresses and chemicals. The present study investigated the possibility of using HSP70 up-regulation... Read More about Increased Heat Shock Protein 70 Expression Following Toxicant-Mediated Cytotoxicity: A Ubiquitous Marker Of Toxicant Exposure?.