Outputs (76)

A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro (2025)
Journal Article
Zhang, Y., Gailloud, L., Shin, A., Fewkes, J., Pinckney, R., Whiting, A., & Chazot, P. (2025). A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro. International Journal of Molecular Sciences, 26(8), 3551. https://doi.org/10.3390/ijms26083551

Vitamin A (retinol) and its derivatives (retinoids) assume critical roles in neural development, cellular differentiation, axon elongation, programmed cell apoptosis and various fundamental cellular processes. Retinoids function by binding to specifi... Read More about A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro.

Precision of the Integrated Cognitive Assessment for the assessment of neurocognitive performance in athletes (2025)
Journal Article
Glassbrook, D. J., Chazot, P. L., & Hind, K. (online). Precision of the Integrated Cognitive Assessment for the assessment of neurocognitive performance in athletes. Applied Neuropsychology: Adult, https://doi.org/10.1080/23279095.2025.2464884

This study investigated the precision of the Integrated Cognitive Assessment (ICA; Cognetivity Neurosciences Ltd., Vancouver, Canada) test for the assessment of information processing ability in athletes. Thirty-one participants took part in this stu... Read More about Precision of the Integrated Cognitive Assessment for the assessment of neurocognitive performance in athletes.

Insights from the eyes: a systematic review and meta-analysis of the intersection between eye-tracking and artificial intelligence in dementia. (2025)
Journal Article
Norouzi, M., Kafieh, R., Chazot, P., Smith, D. T., & Amini, Z. (online). Insights from the eyes: a systematic review and meta-analysis of the intersection between eye-tracking and artificial intelligence in dementia. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2025.2464704

Objectives
Dementia can change oculomotor behavior, which is detectable through eye-tracking. This study aims to systematically review and conduct a meta-analysis of current literature on the intersection between eye-tracking and artificial intellig... Read More about Insights from the eyes: a systematic review and meta-analysis of the intersection between eye-tracking and artificial intelligence in dementia..

ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans ( C. elegans) (2024)
Journal Article
Ladagu, A., Olopade, F., Chazot, P., Elufioye, T., Luong, T., Fuller, M., Halprin, E., Mckay, J., Ates-Alagoz, Z., Gilbert, T., Adejare, A., & Olopade, J. (2024). ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans ( C. elegans). BMC Neuroscience, 25(1), Article 56. https://doi.org/10.1186/s12868-024-00902-y

Introduction: Vanadium is a widely used transition metal in industrial applications, but it also poses significant neurotoxic and environmental risks. Previous studies have shown that exposure to vanadium may lead to neurodegenerative diseases and ne... Read More about ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans ( C. elegans).

Assessing the feasibility of the GOTT (Gabapentinoid and Opioid Tapering Toolkit) in a primary care setting in North-East England (2024)
Journal Article
Johnson, L., Cole, F., Kinchin, R., Francis, A., Winiarek, K., Hampshire, K., & Chazot, P. (2025). Assessing the feasibility of the GOTT (Gabapentinoid and Opioid Tapering Toolkit) in a primary care setting in North-East England. British Journal of Pain, 19(1), 29-42. https://doi.org/10.1177/20494637241291534

To assess the feasibility and possible impacts of implementation of systematic non-pharmacological interventions to reduce the level of prescribing of opioid and gabapentinoid analgesics for chronic non-cancer pain (CNCP), particularly high-dose pres... Read More about Assessing the feasibility of the GOTT (Gabapentinoid and Opioid Tapering Toolkit) in a primary care setting in North-East England.

CaMKIIα‐TARPγ8 signaling mediates hippocampal synaptic impairment in aging (2024)
Journal Article
JianHua, Z., Li, M., Hu, Q., Donoghue, P., Jiang, S., Li, J., Li, S., Ren, X., Zhang, Z., Du, J., Yu, Y., Chazot, P., & Lu, C. (2025). CaMKIIα‐TARPγ8 signaling mediates hippocampal synaptic impairment in aging. Aging Cell, 24(1), Article e14349. https://doi.org/10.1111/acel.14349

Aging‐related decline in memory and synaptic function are associated with the dysregulation of calcium homeostasis, attributed to the overexpression of voltage‐gated calcium channels (VGCC). The membrane insertion of AMPAR governed by the AMPAR auxil... Read More about CaMKIIα‐TARPγ8 signaling mediates hippocampal synaptic impairment in aging.

Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease (2024)
Journal Article
Escudier, O., Zhang, Y., Whiting, A., & Chazot, P. (2024). Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease. International Journal of Molecular Sciences, 25(18), Article 9764. https://doi.org/10.3390/ijms25189764

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease worldwide and is characterized by progressive muscle atrophy. There are currently two approved treatments, but they only relieve symptoms briefly and do not cure the disease.... Read More about Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease.

Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study (2024)
Journal Article
Alanazi, N., Fitzgerald, M., Hume, P., Hellewell, S., Horncastle, A., Anyaegbu, C., Papini, M. G., Hargreaves, N., Halicki, M., Entwistle, I., Hind, K., & Chazot, P. (2024). Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study. International Journal of Molecular Sciences, 25(14), Article 7811. https://doi.org/10.3390/ijms25147811

The health and well-being of retired rugby union and league players, particularly regarding the long-term effects of concussions, are of major concern. Concussion has been identified as a major risk factor for neurodegenerative diseases, such as Alzh... Read More about Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study.

Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models (2023)
Journal Article
Chindo, B. A., Howes, M. R., Abuhamdah, S., Mallam, D., Micah, T., Awotula, R. I., …Chazot, P. L. (2024). Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of Ethnopharmacology, 321, Article 117500. https://doi.org/10.1016/j.jep.2023.117500

Ethnopharmacological relevance
Melissa officinalis L. (Lamiaceae) is a medicinal plant native to Mediterranean regions and found in other parts of the world. Extracts and essential oil from this widely cultivated culinary medicinal herb are used in... Read More about Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.

Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist (2023)
Journal Article
Digal Ladagu, A., Eniola Olopade, F., Chazot, P., Oyagbemi, A. A., Ohiomokhare, S., Racheal Folarin, O., …Olopade, J. O. (2023). Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist. International Journal of Molecular Sciences, 24(23), Article 16710. https://doi.org/10.3390/ijms242316710

Exposure to heavy metals, such as vanadium, poses an ongoing environmental and health threat, heightening the risk of neurodegenerative disorders. While several compounds have shown promise in mitigating vanadium toxicity, their efficacy is limited.... Read More about Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist.