Outputs (9)

Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity (2016)
Journal Article
Veglia, E., Pini, A., Moggio, A., Grange, C., Premoselli, F., Miglio, G., …Rosa, A. C. (2016). Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity. Pharmacological Research, 114, 27-38. https://doi.org/10.1016/j.phrs.2016.10.011

Histamine has been reported to decrease the ultrafiltration coefficient, which inversely correlates with glomerular permselectivity, however the mechanism(s) underling this effect have never been investigated. This study aimed to assess whether hista... Read More about Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity.

Slope climbing challenges, fear of heights, anxiety and time of the day (2016)
Journal Article
Ennaceur, A., Hussain, M., Abuhamdah, R., Mostafa, R., & Chazot, P. (2017). Slope climbing challenges, fear of heights, anxiety and time of the day. Behavioural Brain Research, 316, 169-182. https://doi.org/10.1016/j.bbr.2016.09.010

When exposed to an unfamiliar open space, animals experience fear and attempt to find an escape route. Anxiety emerges when animals are confronted with a challenging obstacle to this fear motivated escape. High anxiety animals do not take risks; they... Read More about Slope climbing challenges, fear of heights, anxiety and time of the day.

Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies (2016)
Journal Article
Lethbridge, N., & Chazot, P. (2016). Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies. Pharmacological Research, 113(Part A), 245-256. https://doi.org/10.1016/j.phrs.2016.08.034

Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparativ... Read More about Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.

Role of Histamine H4 Receptor ligands in Bleomycin-induced pulmonary fibrosis (2016)
Journal Article
Lucarini, L., Pini, A., Rosa, A., Lanzi, C., Durante, M., Chazot, P., …Masini, E. (2016). Role of Histamine H4 Receptor ligands in Bleomycin-induced pulmonary fibrosis. Pharmacological Research, 111, 740-748. https://doi.org/10.1016/j.phrs.2016.07.037

Fibrosis of lung tissue is a disease where a chronic inflammatory process determines a pathological remodelling of lung parenchyma. The animal model obtained by intra-tracheal administration of bleomycin in C57BL/6 mice is one of the most validated m... Read More about Role of Histamine H4 Receptor ligands in Bleomycin-induced pulmonary fibrosis.

Histamine in diabetes: is it time to reconsider? (2016)
Journal Article
Pini, A., Obara, I., Battell, E., Chazot, P., & Rosa, A. (2016). Histamine in diabetes: is it time to reconsider?. Pharmacological Research, 111, 316-324. https://doi.org/10.1016/j.phrs.2016.06.021

The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a... Read More about Histamine in diabetes: is it time to reconsider?.

Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine (2016)
Journal Article
Abuhamdah, R., Hussain, M., Chazot, P., & Ennaceur, A. (2016). Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine. Physiology & Behavior, 164(Part A), 353-360. https://doi.org/10.1016/j.physbeh.2016.06.017

Familiarity can imply a reduction of fear and anxiety, which may render learning and memory performance insensitive to NMDA receptor antagonism. Our previous study indicates that MK-801 (dizocilpine), NMDA antagonist, increased anxiety and prevented... Read More about Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine.

Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats (2016)
Journal Article
Cork, S., Chazot, P., & Pyner, S. (2016). Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats. Neuroscience Letters, 620, 148-153. https://doi.org/10.1016/j.neulet.2016.03.031

A characteristic of both hypertension and pregnancy is increased sympathetic nerve activity. The level of sympathetic activation is determined, in part, by a tonic GABAergic inhibition arising from the hypothalamic paraventricular nucleus (PVN). In h... Read More about Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats.

Preclinical animal anxiety research - flaws and prejudices (2016)
Journal Article
Ennaceur, A., & Chazot, P. (2016). Preclinical animal anxiety research - flaws and prejudices. Pharmacology Research and Perspectives, 4(2), https://doi.org/10.1002/prp2.223

The current tests of anxiety in mice and rats used in preclinical research include the elevated plus-maze (EPM) or zero-maze (EZM), the light/dark box (LDB), and the open-field (OF). They are currently very popular, and despite their poor achievement... Read More about Preclinical animal anxiety research - flaws and prejudices.

Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons. (2016)
Journal Article
Wang, J., Wang, Y., Xu, F., Zhao, J., Zhou, S., Yu, Y., …Lu, C. (2016). Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons. Acta Pharmacologica Sinica, 37(3), 303-311. https://doi.org/10.1038/aps.2015.112

Aim: Transmembrane AMPA receptor regulatory proteins (TARPs) regulate the trafficking and expression of AMPA receptors that are essential for the fast excitatory synaptic transmission and plasticity in the brain. This study aimed to investigate the a... Read More about Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons..