Outputs (2)

Modularity of Zorya defense systems during phage inhibition (2025)
Journal Article
Mariano, G., Deme, J. C., Readshaw, J. J., Grobbelaar, M. J., Keenan, M., El-Masri, Y., Bamford, L., Songra, S., Blower, T. R., Palmer, T., & Lea, S. M. (2025). Modularity of Zorya defense systems during phage inhibition. Nature Communications, 16(1), Article 2344. https://doi.org/10.1038/s41467-025-57397-2

Bacteria have evolved an extraordinary diversity of defense systems against bacteriophage (phage) predation. However, the molecular mechanisms underlying these anti-phage systems often remain elusive. Here, we provide mechanistic and structural insig... Read More about Modularity of Zorya defense systems during phage inhibition.

Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition (2023)
Journal Article
Beck, I. N., Arrowsmith, T. J., Grobbelaar, M. J., Bromley, E. C., Marles-Wright, J., & Blower, T. R. (2024). Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition. Nucleic Acids Research, 52(4), 1909-1929. https://doi.org/10.1093/nar/gkad1220

Mycobacterium tuberculosis, the causative agent of tuberculosis, is a growing threat to global health, with recent efforts towards its eradication being reversed in the wake of the COVID-19 pandemic. Increasing resistance to gyrase-targeting second-l... Read More about Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition.