Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes
(2016)
Journal Article
Meyer, S. K., Probert, P. M., Lakey, A. K., Leitch, A. C., Blake, L. I., Jowsey, P. A., Cooke, M. P., Blain, P. G., & Wright, M. C. (2017). Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes. Toxicological Sciences, 156(1), 54-71. https://doi.org/10.1093/toxsci/kfw234
High systemic levels of oestrogens are cholestatic and primary biliary cholangitis (PBC)—which is characterized by hepatic ductular inflammation—is thought to be triggered by exposure to xenobiotics such as those around landfill sites. Xenoestrogens... Read More about Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes.