Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
(2023)
Journal Article
Tsai, M.-H. C., Caswell, S. J., Morris, E. R., Mann, M. C., Pennell, S., Kelly, G., Groom, H. C., Taylor, I. A., & Bishop, K. N. (2023). Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells. Retrovirology, 20(1), Article 5. https://doi.org/10.1186/s12977-023-00620-z
SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these cells i... Read More about Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells.