Outputs (2)

A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements (2025)
Journal Article
Clough, S. E., Young, T. R., Tarrant, E., Scott, A. J. P., Chivers, P. T., Glasfeld, A., & Robinson, D. J. (2025). A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements. Nature Communications, 16(1), Article 810. https://doi.org/10.1038/s41467-025-56199-w

It has been challenging to test how proteins acquire specific metals in cells. The speciation of metalation is thought to depend on the preferences of proteins for different metals competing at intracellular metal-availabilities. This implies mis-met... Read More about A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements.

Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment (2018)
Journal Article
Dembek, M., Kelly, A., Barwinska‐Sendra, A., Tarrant, E., Stanley, W. A., Vollmer, D., …Salgado, P. S. (2018). Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment. Molecular Microbiology, 110(3), 390-410. https://doi.org/10.1111/mmi.14091

Clostridium difficile remains the leading cause of antibiotic-associated diarrhoea in hospitals worldwide, linked to significant morbidity and mortality. As a strict anaerobe, it produces dormant cell forms - spores - which allow it to survive in the... Read More about Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment.