Outputs (2)

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence (2024)
Journal Article
Went, S. C., Picton, D. M., Morgan, R. D., Nelson, A., Brady, A., Mariano, G., Dryden, D. T. F., Smith, D. L., Wenner, N., Hinton, J. C. D., & Blower, T. R. (2024). Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence. Nature Communications, 15, Article 7236. https://doi.org/10.1038/s41467-024-51629-7

Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognise and methylate 6 bp non-palindromic motifs within the host genome, and prevent replicat... Read More about Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence.

Generation of tools for expression and purification of the phage-encoded Type I restriction enzyme inhibitor, Ocr (2024)
Journal Article
Alves, J., Dry, I., White, J. H., Dryden, D. T., & Lynskey, N. N. (2024). Generation of tools for expression and purification of the phage-encoded Type I restriction enzyme inhibitor, Ocr. Microbiology, 170(7), https://doi.org/10.1099/mic.0.001465

DNA manipulation is an essential tool in molecular microbiology research that is dependent on the ability of bacteria to take up and preserve foreign DNA by horizontal gene transfer. This process can be significantly impaired by the activity of bacte... Read More about Generation of tools for expression and purification of the phage-encoded Type I restriction enzyme inhibitor, Ocr.