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Dominant effect of gap junction communication in wound‐induced calcium‐wave, NFAT activation and wound closure in keratinocytes (2021)
Journal Article
Hudson, L., Begg, M., Wright, B., Cheek, T., Jahoda, C. A., & Reynolds, N. J. (2021). Dominant effect of gap junction communication in wound‐induced calcium‐wave, NFAT activation and wound closure in keratinocytes. Journal of Cellular Physiology, 236(12), 8171-8183. https://doi.org/10.1002/jcp.30488

Wounding induces a calcium wave and disrupts the calcium gradient across the epidermis but mechanisms mediating calcium and downstream signalling, and longer-term wound healing responses are incompletely understood. As expected, live-cell confocal im... Read More about Dominant effect of gap junction communication in wound‐induced calcium‐wave, NFAT activation and wound closure in keratinocytes.

Tissue engineering of human hair follicles using a biomimetic developmental approach (2018)
Journal Article
Abaci, H. E., Coffman, A., Doucet, Y., Chen, J., Jacków, J., Wang, E., Guo, Z., Shin, J. U., Jahoda, C. A., & Christiano, A. M. (2018). Tissue engineering of human hair follicles using a biomimetic developmental approach. Nature Communications, 9(1), Article 5301. https://doi.org/10.1038/s41467-018-07579-y

Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such... Read More about Tissue engineering of human hair follicles using a biomimetic developmental approach.

Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures (2018)
Journal Article
Liu, J., Higgins, C. A., Whitehouse, J. C., Harris, S. J., Crawford, H., Christiano, A. M., Lako, M., Hole, N., & Jahoda, C. A. (2018). Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures. Stem Cells International, 2018, Article 8631432. https://doi.org/10.1155/2018/8631432

In the hair follicle, the dermal papilla (DP) and dermal sheath (DS) support and maintain proliferation and differentiation of the epithelial stem cells that produce the hair fibre. In view of their regulatory properties, in this study, we investigat... Read More about Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures.

Hierarchical patterning modes orchestrate hair follicle morphogenesis (2017)
Journal Article
Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., …Headon, D. J. (2017). Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS Biology, 15(7), Article e2002117. https://doi.org/10.1371/journal.pbio.2002117

Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing reaction–diffusion system posits that interacting diffusible signals produced by static cells first defin... Read More about Hierarchical patterning modes orchestrate hair follicle morphogenesis.

Multifaceted role of hair follicle dermal cells in bioengineered skins (2017)
Journal Article
Higgins, C., Roger, M., Hill, R., Ali-Khan, A., Garlick, J., Christiano, A., & Jahoda, C. (2017). Multifaceted role of hair follicle dermal cells in bioengineered skins. British Journal of Dermatology, 176(5), 1259-1269. https://doi.org/10.1111/bjd.15087

Background The method of generating bioengineered skin constructs was pioneered several decades ago; nowadays these constructs are used regularly for the treatment of severe burns and nonhealing wounds. Commonly, these constructs are comprised of ski... Read More about Multifaceted role of hair follicle dermal cells in bioengineered skins.

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium (2015)
Journal Article
Mardaryev, A., Liu, B., Rapisarda, V., Poterlowicz, K., Malashchuk, I., Rudolf, J., …Botchkarev, V. (2016). Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. Journal of Cell Biology, 212(1), 77-89. https://doi.org/10.1083/jcb.201506065

During development, multipotent progenitor cells establish lineage-specific programmers of gene activation and silencing underlying their differentiation into specialized cell types. We show that the Polycomb component Cbx4 serves as a critical deter... Read More about Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.

Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4 (2013)
Journal Article
Wojciechowicz, K., Gledhill, K., Ambler, C., Manning, C., & Jahoda, C. (2013). Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4. PLoS ONE, 8(3), Article e59811. https://doi.org/10.1371/journal.pone.0059811

The laboratory mouse is a key animal model for studies of adipose biology, metabolism and disease, yet the developmental changes that occur in tissues and cells that become the adipose layer in mouse skin have received little attention. Moreover, the... Read More about Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4.