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A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction (2015)
Journal Article
Nelis, S., Conti, L., Zhang, C., & Sadanandom, A. (2015). A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction. Plant Signaling & Behavior, 10(2), https://doi.org/10.4161/15592324.2014.987528

Plants survive adversity by modulating their growth in response to changing environmental signals. The phytohormone Gibberellic acid (GA) plays a central role in regulating these adaptive responses by stimulating the degradation of growth repressing... Read More about A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction.

Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici (2015)
Journal Article
Lee, J., Orosa, B., Millyard, L., Edwards, M., Kanyuka, K., Gatehouse, A., …Sadanandom, A. (2015). Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici. New Phytologist, 206(2), 598-605. https://doi.org/10.1111/nph.13323

A distinguishing feature of Septoria leaf blotch disease in wheat is the long symptomless growth of the fungus amongst host cells followed by a rapid transition to necrotrophic growth resulting in disease lesions. Global reprogramming of host transcr... Read More about Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici.

Ubiquitin chain topology in plant cell signaling: a new facet to an evergreen story (2014)
Journal Article
Walsh, C., & Sadanandom, A. (2014). Ubiquitin chain topology in plant cell signaling: a new facet to an evergreen story. Frontiers in Plant Science, 5, https://doi.org/10.3389/fpls.2014.00122

Ubiquitin is a peptide modifier able to form polymers of varying length and linkage as part of a powerful signaling system. Perhaps the best-known aspect of this protein's function is as the driver of targeted protein degradation through the Ubiquiti... Read More about Ubiquitin chain topology in plant cell signaling: a new facet to an evergreen story.

Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin (2014)
Journal Article
Conti, L., Nelis, S., Zhang, C., Woodcock, A., Swarup, R., Galbiati, M., …Sadanandom, A. (2014). Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin. Developmental Cell, 28(1), 102-110. https://doi.org/10.1016/j.devcel.2013.12.004

Plants survive adverse conditions by modulating their growth in response to a changing environment. Gibberellins (GAs) play a key role in these adaptive responses by stimulating the degradation of growth-repressing DELLA proteins. GA binding to its r... Read More about Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin.

Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling (2013)
Journal Article
Laird, J., McInally, C., Carr, C., Doddiah, S., Yates, G., Chrysanthou, E., …Milner, J. (2013). Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling. Journal of General Virology, 94(12), 2777-2789. https://doi.org/10.1099/vir.0.057729-0

Cauliflower mosaic virus (CaMV) encodes a 520 aa polypeptide, P6, which participates in several essential activities in the virus life cycle including suppressing RNA silencing and salicylic acid-responsive defence signalling. We infected Arabidopsis... Read More about Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling.

Ubiquitination in plant nutrient utilization (2013)
Journal Article
Yates, G., & Sadanandom, A. (2013). Ubiquitination in plant nutrient utilization. Frontiers in Plant Science, 4, https://doi.org/10.3389/fpls.2013.00452

Ubiquitin (Ub) is well-established as a major modifier of signaling in eukaryotes. However, the extent to which plants rely on Ub for regulating nutrient uptake is still in its infancy. The main characteristic of ubiquitination is the conjugation of... Read More about Ubiquitination in plant nutrient utilization.

The ubiquitin-proteasome system: central modifier of plant signalling. (2012)
Journal Article
Sadanandom, A., Bailey, M., Ewan, R., Lee, J., & Nelis, S. (2012). The ubiquitin-proteasome system: central modifier of plant signalling. New Phytologist, 196(1), 13-28. https://doi.org/10.1111/j.1469-8137.2012.04266.x

Ubiquitin is well established as a major modifier of signalling in eukaryotes. However, the extent to which plants rely on ubiquitin for regulating their lifecycle is only recently becoming apparent. This is underlined by the over-representation of g... Read More about The ubiquitin-proteasome system: central modifier of plant signalling..

Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity (2012)
Journal Article
Love, A., Geri, C., Laird, J., Carr, C., Yun, B., Loake, G., …Milner, J. (2012). Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity. PLoS ONE, 7(10), https://doi.org/10.1371/journal.pone.0047535

Cauliflower mosaic virus (CaMV) encodes a multifunctional protein P6 that is required for translation of the 35S RNA and also acts as a suppressor of RNA silencing. Here we demonstrate that P6 additionally acts as a pathogenicity effector of an uniqu... Read More about Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity.

CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a (2011)
Journal Article
Gilroy, E., Taylor, R., Hein, I., Boevink, P., Sadanandom, A., & Birch, P. (2011). CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a. New Phytologist, 190(3), 653-666. https://doi.org/10.1111/j.1469-8137.2011.03643.x