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Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells (2019)
Journal Article
Ayala Orozco, C., Liu, D., Li, Y., Alemany, L. B., Pal, R., Krishnan, S., & Tour, J. M. (2020). Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells. ACS Applied Materials and Interfaces, 12(1), 410-417. https://doi.org/10.1021/acsami.9b21497

Recently, synthetic molecular nanomachines (MNMs) that rotate unidirectionally in response to UV light excitation have been used to produce nanomechanical action on live cells to kill them through the drilling of holes in their cell membranes. In the... Read More about Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells.

Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant Klebsiella pneumoniae to Meropenem (2019)
Journal Article
Galbadage, T., Liu, D., Alemany, L. B., Pal, R., Tour, J. M., Gunasekera, R. S., & Cirillo, J. D. (2019). Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant Klebsiella pneumoniae to Meropenem. ACS Nano, 13(12), 14377-14387. https://doi.org/10.1021/acsnano.9b07836

Multidrug resistance in pathogenic bacteria is an increasing problem in patient care and public health. Molecular nanomachines (MNMs) have the ability to open cell membranes using nanomechanical action. We hypothesized that MNMs could be used as anti... Read More about Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant Klebsiella pneumoniae to Meropenem.

Targeted Luminescent Europium Peptide Conjugates: Comparative Analysis Using Maleimide and para-Nitropyridyl Linkages for Organelle Staining (2019)
Journal Article
Starck, M., Fradgley, J. D., Di Vita, S., Mosely, J., Pal, R., & Parker, D. (2020). Targeted Luminescent Europium Peptide Conjugates: Comparative Analysis Using Maleimide and para-Nitropyridyl Linkages for Organelle Staining. Bioconjugate Chemistry, 31(2), 229-240. https://doi.org/10.1021/acs.bioconjchem.9b00735

The syntheses and photophysical behaviour of nine, strongly luminescent nonadentate Eu(III) complexes are reported. Each complex is based on N-functionalised 1,4,7- triazacyclononane, and linkage to other groups or targeting vectors can occur either... Read More about Targeted Luminescent Europium Peptide Conjugates: Comparative Analysis Using Maleimide and para-Nitropyridyl Linkages for Organelle Staining.

Synthesis of water-soluble chiral DOTA lanthanide complexes with predominately twisted square antiprism isomers and circularly polarized luminescence emission (2019)
Journal Article
Dai, L., Zhang, J., Chen, Y., MacKenzie, L. E., Pal, R., & Law, G.-L. (2019). Synthesis of water-soluble chiral DOTA lanthanide complexes with predominately twisted square antiprism isomers and circularly polarized luminescence emission. Inorganic Chemistry, 58(19), 12506-12510. https://doi.org/10.1021/acs.inorgchem.9b01799

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5– exhibits a high rela... Read More about Synthesis of water-soluble chiral DOTA lanthanide complexes with predominately twisted square antiprism isomers and circularly polarized luminescence emission.

Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group (2019)
Journal Article
Meksawangwong, S., Gohil, B., Punyain, W., Pal, R., & Kielar, F. (2019). Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group. Inorganica Chimica Acta, 497, Article 119066. https://doi.org/10.1016/j.ica.2019.119066

A novel tris-cyclometalated iridium complex (1) containing a single quarternary ammonium moiety has been synthesized, characterized, and investigated as a potential cellular imaging probe. The complex is the next generation of the aminoalkyl iridium... Read More about Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group.

π‐Expanded Thioxanthones ‐ Engineering the Triplet Level of Thioxanthone Sensitizers for Lanthanide‐Based Luminescent Probes with Visible Excitation (2019)
Journal Article
Dansholm, C. N., Junker, A. K. R., Nielsen, L. G., Kofod, N., Pal, R., & Sørensen, T. J. (2019). π‐Expanded Thioxanthones ‐ Engineering the Triplet Level of Thioxanthone Sensitizers for Lanthanide‐Based Luminescent Probes with Visible Excitation. ChemPlusChem, 84(12), 1778-1788. https://doi.org/10.1002/cplu.201900309

Bright lanthanide based probes for optical bioimaging must rely on the antenna principle, where the lanthanide‐centred excited state is formed by a complex sensitization process. Efficient sensitization of lanthanide‐centred emission occurs via tripl... Read More about π‐Expanded Thioxanthones ‐ Engineering the Triplet Level of Thioxanthone Sensitizers for Lanthanide‐Based Luminescent Probes with Visible Excitation.

Near Infrared Light Activates Molecular Nanomachines to Drill Into and Kill Cells (2019)
Journal Article
Liu, D., García-López, V., Gunasekera, R. S., Greer Nilewski, L., Alemany, L. B., Aliyan, A., Jin, T., Wang, G., Tour, J. M., & Pal, R. (2019). Near Infrared Light Activates Molecular Nanomachines to Drill Into and Kill Cells. ACS Nano, 13(6), 6813-6823. https://doi.org/10.1021/acsnano.9b01556

Using two-photon excitation (2PE), molecular nanomachines (MNMs) are able to drill through cell membranes and kill the cells. This avoids the use of the more damaging ultraviolet (UV) light that has been used formerly to induce this nanomechanical ce... Read More about Near Infrared Light Activates Molecular Nanomachines to Drill Into and Kill Cells.

Holographic projection for multi-spot structured illumination microscopy (2019)
Journal Article
Ward, E., & Pal, R. (2019). Holographic projection for multi-spot structured illumination microscopy. Journal of Microscopy, 274(2), 114-120. https://doi.org/10.1111/jmi.12787

This paper describes the design and testing of a multi‐spot structured illumination microscopy system using computer‐generated holograms to create the required excitation patterns. Furthermore, it demonstrates the use of an adapted direct search algo... Read More about Holographic projection for multi-spot structured illumination microscopy.