Outputs (3)

Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases (2025)
Journal Article
Butler, A. M., Chisholm, D. R., Tomlinson, C. W., Khatib, T., Clark, J., Wan, S., Coveney, P. V., Greig, I. R., McCaffery, P., Pohl, E., & Whiting, A. (online). Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases. ACS Omega, https://doi.org/10.1021/acsomega.5c00934

Retinoids, such as all-trans retinoic acid (ATRA), are the active metabolite forms of endogenous Vitamin A and function as key signaling molecules involved in the regulation of a variety of cellular processes. Due to their highly diverse biological r... Read More about Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases.

Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes (2025)
Journal Article
Isern, J. A., Porta, E. O., Kalesh, K., Koutsogiannis, Z., Cazzola, D., Pohl, E., Denny, P., & Steel, P. G. (2025). Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes. ChemBioChem, 26(10), Article e202500160. https://doi.org/10.1002/cbic.202500160

Leishmaniasis, a vector borne neglected tropical disease, caused by the protozoan parasite Leishmania, is a major global public health challenge with millions of new cases annually. Treatment of leishmaniasis is difficult for many reasons including a... Read More about Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes.

Novel metal sites revealed by spectroscopic and structural characterization of the ferric uptake regulator from Acidithiobacillus ferrooxidans (2025)
Journal Article
Argandoña, Y., Olivos, A., Obando, P., Imas, F., Pohl, E., Quatrini, R., & Arenas-Salinas, M. (2025). Novel metal sites revealed by spectroscopic and structural characterization of the ferric uptake regulator from Acidithiobacillus ferrooxidans. Computational and Structural Biotechnology Journal, 27, 765-777. https://doi.org/10.1016/j.csbj.2025.02.017

Acidithiobacillus ferrooxidans (Af.) is a microorganism of significant biotechnological interest that thrives in acidic environments with very high concentrations of soluble iron. Understanding the molecular mechanisms that enable its survival in the... Read More about Novel metal sites revealed by spectroscopic and structural characterization of the ferric uptake regulator from Acidithiobacillus ferrooxidans.