Outputs (3)

A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria (2024)
Journal Article
Leslie, K. G., Jolliffe, K. A., Müllner, M., New, E. J., Turnbull, W. B., Fascione, M. A., Friman, V.-P., & Mahon, C. S. (2024). A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria. Biomacromolecules, 25(11), 7466-7474. https://doi.org/10.1021/acs.biomac.4c01129

Identification of bacterial lectins offers an attractive route to the development of new diagnostics, but the design of specific sensors is complicated by the low selectivity of carbohydrate-lectin interactions. Here we describe a glycopolymer-based... Read More about A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria.

Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design? (2024)
Journal Article
Leslie, K. G., Berry, S. S., Miller, G. J., & Mahon, C. S. (2024). Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?. Journal of the American Chemical Society, 146(40), 27215-27232. https://doi.org/10.1021/jacs.4c08818

Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools and techniques toward the... Read More about Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?.

Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation (2024)
Journal Article
Wootton, H. S., Berry, S. S., Ferguson, E. L., Mahon, C. S., & Miller, G. J. (2024). Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation. European Journal of Organic Chemistry, 27(40), Article e202400587. https://doi.org/10.1002/ejoc.202400587

A divergent synthetic route to chondroitin sulfate (CS) disaccharide precursors, including rarer subtypes such as CS-D, has been developed. From common intermediates, a series of thioglycoside D-glucosyl donors and 4,6-O-benzylidene protected D-galac... Read More about Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation.