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Outputs (6)

Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial (2024)
Journal Article
Austin, D., Maier, R. H., Akhter, N., Sayari, M., Ogundimu, E., Maddox, J. M., Vahabi, S., Humphreys, A. C., Graham, J., Oxenham, H., Haney, S., Cresti, N., Verrill, M., Osborne, W., Wright, K. L., Goranova, R., Bailey, J. R., Kalakonda, N., Macheta, M., Kilner, M. F., …Plummer, C. (2024). Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial. Journal of the American College of Cardiology, 6(5), 684-696. https://doi.org/10.1016/j.jaccao.2024.07.010

Background
Cardiotoxicity is a concern for cancer survivors undergoing anthracycline chemotherapy. Enalapril has been explored for its potential to mitigate cardiotoxicity in cancer patients. The dose-dependent cardiotoxicity effec... Read More about Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial.

Lack of effect of a parent‐delivered early language intervention: Evidence from a randomised controlled trial completed during COVID‐19 (2024)
Journal Article
Burgoyne, K., Hargreaves, S., Akhter, N., Cramman, H., Eerola, P., Einbeck, J., & Menzies, V. (online). Lack of effect of a parent‐delivered early language intervention: Evidence from a randomised controlled trial completed during COVID‐19. JCPP Advances, Article e12279. https://doi.org/10.1002/jcv2.12279

Background: Parents play a key role in their child's early development but evidence that parental engagement strategies are effective is unclear. The current study evaluated a parent‐delivered early language teaching programme that aimed to support c... Read More about Lack of effect of a parent‐delivered early language intervention: Evidence from a randomised controlled trial completed during COVID‐19.

Improving power calculations in educational trials (2023)
Report
Singh, A., Uwimpuhwe, G., Vallis, D., Akhter, N., Coolen-Maturi, T., Einbeck, J., Higgins, S., Culliney, M., & Demack, S. (2023). Improving power calculations in educational trials. Education Endowment Foundation

The aim of this study was to investigate and empirically derive parameters commonly used for statistical power and sample size calculations to better inform future trial design. Towards achieving this aim, the research project leveraged the richness... Read More about Improving power calculations in educational trials.

Individual participant data meta-analysis: pooled effect of EEF funded educational trials on low baseline attaining group (2023)
Presentation / Conference Contribution
Uwimpuhwe, G., Singh, A., Akhter, N., Ashraf, B., Coolen-Maturi, T., Robinson, T., Higgins, S., & Einbeck, J. (2023, July). Individual participant data meta-analysis: pooled effect of EEF funded educational trials on low baseline attaining group. Presented at International Workshop on Statistical Modelling, Dortmund

The Education Endowment Foundation (EEF), a charity aiming to break the link between socioeconomic disadvantage and pupil attainment, has commissioned over 200 randomised controlled trials. The collection of data from these trials, the `EEF Data Arch... Read More about Individual participant data meta-analysis: pooled effect of EEF funded educational trials on low baseline attaining group.

Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT) (2022)
Journal Article
Maier, R. H., Plummer, C., Kasim, A. S., Akhter, N., Ogundimu, E., Maddox, J., Graham, J., Stewart, M., Wardley, A., Haney, S., Vahabi, S., Oxenham, H., Humphreys, A., Cresti, N., Verrill, M., Graham, R., Chang, L., Hancock, H. C., & Austin, D. (2022). Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT). BMJ Open, 12(12), Article e066252. https://doi.org/10.1136/bmjopen-2022-066252

Introduction: Anthracyclines are included in chemotherapy regimens to treat several different types of cancer and are extremely effective. However, it is recognised that a significant side effect is cardiotoxicity; anthracyclines can cause irreversib... Read More about Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT).