Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes
(2014)
Journal Article
Mitra, M., Taylor, P., Hutchison, C., McLeish, T., & Chakrabarti, B. (2014). Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes. Journal of the Royal Society. Interface, 11(100), https://doi.org/10.1098/rsif.2014.0706
The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and valley-strewn bott... Read More about Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes.