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Outputs (53)

Trepidation or Precession: The Turning Point in a Tradition (2023)
Book Chapter
Tanner, B., McLeish, T., & Nothaft, P. (2023). Trepidation or Precession: The Turning Point in a Tradition. In G. E. Gasper, T. C. McLeish, S. Olsen Sønnesyn, & H. E. Smithson (Eds.), Mapping the Universe: Robert Grosseteste’s De sphera - On the Sphere (279-304). Oxford: Oxford University Press

This chapter provides historical and scientific commentary on the reference in On the Sphere to the very slow movement of the equinoxes as identified by the change in stellar positions measured in different centuries. It discusses the two different m... Read More about Trepidation or Precession: The Turning Point in a Tradition.

Commentary on the model of the world machine (2023)
Book Chapter
Tanner, B., McLeish, T., Sonnesyn, S., & Falk, S. (2023). Commentary on the model of the world machine. In G. E. M. Gasper, T. C. B. McLeish, S. Olsen Sønnesyn, & H. E. Smithson (Eds.), 'Mapping the Universe: Robert Grosseteste’s De sphera - On the Sphere (132-166). Oxford: Oxford University Press

The chapter provides both a commentary and a science-based explanation of the text of On the Sphere. It contains many diagrams, designed to clarify the geometrical constructions on which the narrative is based. Presented in alignment with the paragra... Read More about Commentary on the model of the world machine.

The ‘allosteron’ model for entropic allostery of self-assembly (2018)
Journal Article
McLeish, T., Schaefer, C., & von der Heydt, A. (2018). The ‘allosteron’ model for entropic allostery of self-assembly. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1749), Article 20170186. https://doi.org/10.1098/rstb.2017.0186

Using the simple ‘allosteron’ model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein... Read More about The ‘allosteron’ model for entropic allostery of self-assembly.

Elasticity dominated surface segregation of small molecules in polymer mixtures (2016)
Journal Article
Krawczyk, J., Croce, S., McLeish, T., & Chakrabarti, B. (2016). Elasticity dominated surface segregation of small molecules in polymer mixtures. Physical Review Letters, 116(20), Article 208301. https://doi.org/10.1103/physrevlett.116.208301

We study the phenomenon of migration of the small molecular weight component of a binary polymer mixture to the free surface using mean field and self-consistent field theories. By proposing a free energy functional that incorporates polymer-matrix e... Read More about Elasticity dominated surface segregation of small molecules in polymer mixtures.

Multi-scale Approaches to Dynamical Transmission of Protein Allostery (2015)
Presentation / Conference Contribution
Townsend, P., Rodgers, T., Pohl, E., Wilson, M., Cann, M., & McLeish, T. (2015). Multi-scale Approaches to Dynamical Transmission of Protein Allostery. In L. Olivares-Quiroz, O. Guzmán-López, & H. E. Jardón-Valadez (Eds.), Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation (141-152). https://doi.org/10.1007/978-3-319-21687-4_8

We review the idea that allosteric interactions can be transmitted not by structural switching but by the more subtle route of modulation of the amplitude of thermally-activated global dynamical modes in allosteric proteins. The effect is naturally a... Read More about Multi-scale Approaches to Dynamical Transmission of Protein Allostery.

Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence (2015)
Journal Article
McLeish, T. (2015). Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence. Interface Focus, 5(6), Article 20150041. https://doi.org/10.1098/rsfs.2015.0041

We examine the analogy between evolutionary dynamics and statistical mechanics to include the fundamental question of ergodicity—the representative exploration of the space of possible states (in the case of evolution this is genome space). Several p... Read More about Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence.

Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes? (2015)
Journal Article
McLeish, T., Cann, M., & Rodgers, T. (2015). Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?. Biophysical Journal, 109(6), 1240-1250. https://doi.org/10.1016/j.bpj.2015.08.009

We examine the contrast between mechanisms for allosteric signaling that involve structural change, and those that do not, from the perspective of allosteric pathways. In particular we treat in detail the case of fluctuation-allostery by which amplit... Read More about Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?.

The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein (2015)
Journal Article
Townsend, P., Rodgers, T., Glover, L., Korhonen, H., Richards, S., Colwell, L., …Cann, M. (2015). The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein. Journal of Biological Chemistry, 290(36), 22225-22235. https://doi.org/10.1074/jbc.m115.669267

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. Both experimental and theoretical evidence demonstrate that allostery can be communicated through altered slow relaxation protein dynamics... Read More about The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein.