Outputs (4)

Peptide and protein building blocks for synthetic biology: From programming biomolecules to self-organized biomolecular systems (2008)
Journal Article
Bromley, E., Channon, K., Moutevelis, E., & Woolfson, D. (2008). Peptide and protein building blocks for synthetic biology: From programming biomolecules to self-organized biomolecular systems. ACS Chemical Biology, 3(1), 38-50. https://doi.org/10.1021/cb700249v

There are several approaches to creating synthetic-biological systems. Here, we describe a molecular-design approach. First, we lay out a possible synthetic-biology space, which we define with a plot of complexity of components versus divergence from... Read More about Peptide and protein building blocks for synthetic biology: From programming biomolecules to self-organized biomolecular systems.

Synthetic biology through biomolecular design and engineering (2008)
Journal Article
Channon, K., Bromley, E., & Woolfson, D. (2008). Synthetic biology through biomolecular design and engineering. Current Opinion in Structural Biology, 18(4), 491-498

Synthetic biology is a rapidly growing field that has emerged in a global, multidisciplinary effort among biologists, chemists, engineers, physicists, and mathematicians. Broadly, the field has two complementary goals: To improve understanding of bio... Read More about Synthetic biology through biomolecular design and engineering.

Electrostatic control of thickness and stiffness in a designed protein fiber (2008)
Journal Article
Papapostolou, D., Bromley, E., Bano, C., & Woolfson, D. (2008). Electrostatic control of thickness and stiffness in a designed protein fiber. Journal of the American Chemical Society, 130(15), 5124-5130. https://doi.org/10.1021/ja0778444

Attempts to design peptide-based fibers from first principles test our understanding of protein folding and assembly, and potentially provide routes to new biomaterials. Several groups have presented such designs based on a-helical and beta-strand bu... Read More about Electrostatic control of thickness and stiffness in a designed protein fiber.

MagicWand: A single, designed peptide that assembles to stable, ordered alpha-helical fibers (2008)
Journal Article
Gribbon, C., Channon, K., Zhang, W., Banwell, E., Bromley, E., Chaudhuri, J., …Woolfson, D. (2008). MagicWand: A single, designed peptide that assembles to stable, ordered alpha-helical fibers. Biochemistry, 47(39), 10365-10371

We describe a straightforward single-peptide design that self-assembles into extended and thickened nano-to-mesoscale fibers of remarkable stability and order. The basic chassis of the design is the well-understood dimeric a-helical coiled-coil motif... Read More about MagicWand: A single, designed peptide that assembles to stable, ordered alpha-helical fibers.