Outputs (3)

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours (2019)
Journal Article
Pervolaraki, E., Hall, S., Foresteire, D., Saito, T., Saido, T., Whittington, M., Lever, C., & Dachtler, J. (2019). Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours. Disease Models and Mechanisms, 12(9), Article dmm040550. https://doi.org/10.1242/dmm.040550

We studied a new App knock-in mice model of Alzheimer’s disease (AppNL-G-F), containing the Swedish KM670/671NL mutation, the Iberian I716F mutation and the Artic E693G mutation, which generates elevated levels of Aβ40 and Aβ42 without the confounds... Read More about Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.

En route to delineating hippocampal roles in spatial learning (2019)
Journal Article
Poulter, S., Austen, J. M., Kosaki, Y., Dachtler, J., Lever, C., & McGregor, A. (2019). En route to delineating hippocampal roles in spatial learning. Behavioural Brain Research, 369, Article 111936. https://doi.org/10.1016/j.bbr.2019.111936

The precise role played by the hippocampus in spatial learning tasks, such as the Morris Water Maze (MWM), is not fully understood. One theory is that the hippocampus is not required for ‘knowing where’ but rather is crucial in ‘getting there’. To ex... Read More about En route to delineating hippocampal roles in spatial learning.

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice (2019)
Journal Article
Pervolaraki, E., Tyson, A., Pibiri, F., Poulter, S., Reichelt, A., Rodgers, R., Clapcote, S., Lever, C., Andreae, L., & Dachtler, J. (2019). The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice. Molecular Autism, 10, Article 8. https://doi.org/10.1186/s13229-019-0261-9

Background: Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and recent genetic and mouse eviden... Read More about The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.