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Substrate-Modulated Thermal Fluctuations Affect Long-Range Allosteric Signaling in Protein Homodimers: Exemplified in CAP (2010)
Journal Article
Toncrova, H., & McLeish, T. C. (2010). Substrate-Modulated Thermal Fluctuations Affect Long-Range Allosteric Signaling in Protein Homodimers: Exemplified in CAP. Biophysical Journal, 98(10), 2317-2326. https://doi.org/10.1016/j.bpj.2010.01.039

The role of conformational dynamics in allosteric signaling of proteins is increasingly recognized as an important and subtle aspect of this ubiquitous phenomenon. Cooperative binding is commonly observed in proteins with twofold symmetry that bind t... Read More about Substrate-Modulated Thermal Fluctuations Affect Long-Range Allosteric Signaling in Protein Homodimers: Exemplified in CAP.

Chain Deformation in Entangled Polymer Melts at Re-entrant Corners (2010)
Journal Article
Clarke, N., De Luca, E., Buxton, G., Hutchings, L., Gough, T., Grillo, I., …McLeish, T. (2010). Chain Deformation in Entangled Polymer Melts at Re-entrant Corners. Macromolecules, 43(3), 1539-1542. https://doi.org/10.1021/ma902324f

Using SANS to map the deformation of individual polymer chains in the vicinity of re-entrant corners in a contraction−expansion flow, we show that stress singularities at such corners, predicted by formulations of fluid dynamics that lack a molecular... Read More about Chain Deformation in Entangled Polymer Melts at Re-entrant Corners.

Fluctuation power spectra reveal dynamical heterogeneity of peptides (2010)
Journal Article
Khatri, B., Yew, Z. T., Krivov, S., McLeish, T., & Paci, E. (2010). Fluctuation power spectra reveal dynamical heterogeneity of peptides. The Journal of Chemical Physics, 133(1), Article 015101. https://doi.org/10.1063/1.3456552

Characterizing the conformational properties and dynamics of biopolymers and their relation to biological activity and function is an ongoing challenge. Single molecule techniques have provided a rich experimental window on these properties, yet they... Read More about Fluctuation power spectra reveal dynamical heterogeneity of peptides.