Skip to main content

Research Repository

Advanced Search

Dr Emmanuel Ogundimu's Outputs (27)

Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial (2024)
Journal Article
Austin, D., Maier, R. H., Akhter, N., Sayari, M., Ogundimu, E., Maddox, J. M., Vahabi, S., Humphreys, A. C., Graham, J., Oxenham, H., Haney, S., Cresti, N., Verrill, M., Osborne, W., Wright, K. L., Goranova, R., Bailey, J. R., Kalakonda, N., Macheta, M., Kilner, M. F., …Plummer, C. (2024). Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial. Journal of the American College of Cardiology, 6(5), 684-696. https://doi.org/10.1016/j.jaccao.2024.07.010

Background
Cardiotoxicity is a concern for cancer survivors undergoing anthracycline chemotherapy. Enalapril has been explored for its potential to mitigate cardiotoxicity in cancer patients. The dose-dependent cardiotoxicity effec... Read More about Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial.

Using a prognostic medical device for early identification of pressure ulcers: protocol for study design. (2024)
Journal Article
Keltie, K., Parker, R., Dervin, H., Pagnamenta, F., Milne, J., Belilios, E., Latimer, L., Wason, J., Ogundimu, E., McParlin, C., & Sims, A. (2024). Using a prognostic medical device for early identification of pressure ulcers: protocol for study design. British Journal of Nursing, 33(12), S8-S18. https://doi.org/10.12968/bjon.2024.0158

Background:
An objective, physiological measurement taken using a medical device may reduce the incidence of pressure ulcers through earlier detection of problems signs before visual signs appear. Research in this field is hampered by variations in... Read More about Using a prognostic medical device for early identification of pressure ulcers: protocol for study design..

Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial. (2024)
Journal Article
Rodgers, J., Cassidy, S., Pelton, M., Goodwin, J., Wagnild, J., Bhattarai, N., …Vale, L. (2024). Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial. EClinicalMedicine, 73, Article 102662. https://doi.org/10.1016/j.eclinm.2024.102662

Autistic people are a high-risk group for self-harm and suicide. There are no evidence-based suicide prevention interventions developed specifically for autistic people. We undertook a pilot feasibility randomised controlled trial of autism adapted s... Read More about Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial..

Nationally Automated Colonoscopy Performance Feedback Increases Polyp Detection: the NED APRIQOT Randomised Controlled Trial. (2024)
Journal Article
Catlow, J., Sharp, L., Wagnild, J., Lu, L., Bhardwaj-Gosling, R., Ogundimu, E., Kasim, A., Brookes, M., Lee, T., McCarthy, S., Gray, J., Sniehotta, F., Valori, R., Westwood, C., McNally, R., Ruwende, J., Sinclair, S., Deane, J., & Rutter, M. (2024). Nationally Automated Colonoscopy Performance Feedback Increases Polyp Detection: the NED APRIQOT Randomised Controlled Trial. Clinical Gastroenterology and Hepatology, 22(9), 1926-1936. https://doi.org/10.1016/j.cgh.2024.03.048

Post-colonoscopy colorectal cancer incidence and mortality rates are higher for endoscopists with low polyp detection rates. Using the UK's National Endoscopy Database (NED), which automatically captures real-time data, we assessed if providing feedb... Read More about Nationally Automated Colonoscopy Performance Feedback Increases Polyp Detection: the NED APRIQOT Randomised Controlled Trial..

Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol (2024)
Journal Article
Witharana, P., Chang, L., Maier, R., Ogundimu, E., Wilkinson, C., Athanasiou, T., & Akowuah, E. (2024). Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol. BMJ Open, 14(4), Article e079404. https://doi.org/10.1136/bmjopen-2023-079404

Introduction: Cardiac rehabilitation (CR) delivered by rehabilitation specialists in a healthcare setting is effective in improving functional capacity and reducing readmission rates after cardiac surgery. It is also associated with a reduction in ca... Read More about Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol.

Effects of a novel, brief psychological therapy (Managing Unusual Sensory Experiences) for hallucinations in first episode psychosis (MUSE FEP): findings from an exploratory randomised controlled trial. (2024)
Journal Article
Dudley, R., Dodgson, G., Common, S., Ogundimu, E., Liley, J., O’Grady, L., Watson, F., Gibbs, C., Arnott, B., Fernyhough, C., Alderson-Day, B., & Aynsworth, C. (2024). Effects of a novel, brief psychological therapy (Managing Unusual Sensory Experiences) for hallucinations in first episode psychosis (MUSE FEP): findings from an exploratory randomised controlled trial. Journal of Psychiatric Research, 174, 289-296. https://doi.org/10.1016/j.jpsychires.2024.04.031

Hallucinations are a common feature of psychosis, yet access to effective psychological treatment is limited. The Managing Unusual Sensory Experiences for First-Episode-Psychosis (MUSE-FEP) trial aimed to establish the feasibility and acceptability o... Read More about Effects of a novel, brief psychological therapy (Managing Unusual Sensory Experiences) for hallucinations in first episode psychosis (MUSE FEP): findings from an exploratory randomised controlled trial..

A randomised controlled trial of prehabilitation in patients undergoing elective cardiac surgery (2023)
Journal Article
Akowuah, E., Wagnild, J., Bardgett, M., Prichard, J., Mathias, A., Harrison, S., …Maier, R. (2023). A randomised controlled trial of prehabilitation in patients undergoing elective cardiac surgery. Anaesthesia: Peri-operative medicine, critical care and pain, 78(9), 1120-1128. https://doi.org/10.1111/anae.16072

The feasibility, safety and efficacy of prehabilitation in adult patients awaiting elective cardiac surgery are unknown. A total of 180 participants undergoing elective cardiac surgery were allocated randomly to receive either standard pre-operative... Read More about A randomised controlled trial of prehabilitation in patients undergoing elective cardiac surgery.

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction (2023)
Journal Article
Bawamia, B., Spray, L., Wangsaputra, V. K., Bennaceur, K., Vahabi, S., Stellos, K., …Spyridopoulos, I. (2023). Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction. GeroScience, 45(4), 2689-2705. https://doi.org/10.1007/s11357-023-00794-6

Myocardial infarction (MI) accelerates immune ageing characterised by lymphopenia, expansion of terminally differentiated CD8+ T-lymphocytes (CD8+ TEMRA) and inflammation. Pre-clinical data showed that TA-65, an oral telomerase activator, reduced imm... Read More about Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction.

Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial (2023)
Journal Article
Rodgers, J., Goodwin, J., Nielsen, E., Bhattarai, N., Heslop, P., Kharatikoopaei, E., …Cassidy, S. (2023). Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 9(1), Article 31. https://doi.org/10.1186/s40814-023-01264-8

Background: Suicide prevention is a national priority for the UK government. Autistic people are at greater risk of experiencing self-harm and suicidal thoughts and behaviours than the general population. Safety plans are widely used in suicide preve... Read More about Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial.

Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol (2023)
Journal Article
Akowuah, E., Mathias, A., Bardgett, M., Harrison, S., Kasim, A. S., Loughran, K., …Maier, R. H. (2023). Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol. BMJ Open, 13(1), Article e065992. https://doi.org/10.1136/+bmjopen-2022-065992

Introduction: Prehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impac... Read More about Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol.

Long-term outcomes of mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial (2022)
Journal Article
Telyuk, P., Hancock, H., Maier, R., Batty, J. A., Goodwin, A., Owens, W. A., …Akowuah, E. (2023). Long-term outcomes of mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial. European Journal of Cardio-Thoracic Surgery, 63(1), Article ezac540. https://doi.org/10.1093/ejcts/ezac540

Objectives Aortic valve replacement (AVR) for severe symptomatic aortic stenosis is one of the most common cardiac surgical procedures with excellent long-term outcomes. Multiple previous studies have compared short-term outcomes of AVR with mini-ste... Read More about Long-term outcomes of mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial.

Managing Unusual Sensory Experiences in People with First-Episode Psychosis (MUSE FEP): a study protocol for a single-blind parallel-group randomised controlled feasibility trial (2022)
Journal Article
Dudley, R., Dodgson, G., Common, S., O'Grady, L., Watson, F., Gibbs, C., …Aynsworth, C. (2022). Managing Unusual Sensory Experiences in People with First-Episode Psychosis (MUSE FEP): a study protocol for a single-blind parallel-group randomised controlled feasibility trial. BMJ Open, 12(5), Article e061827. https://doi.org/10.1136/bmjopen-2022-061827

Introduction Hallucinations (hearing or seeing things that others do not) are a common feature of psychosis, causing significant distress and disability. Existing treatments such as cognitive–behavioural therapy for psychosis (CBTp) have modest benef... Read More about Managing Unusual Sensory Experiences in People with First-Episode Psychosis (MUSE FEP): a study protocol for a single-blind parallel-group randomised controlled feasibility trial.

On Lasso and adaptive Lasso for non-random sample in credit scoring (2022)
Journal Article
Ogundimu, E. O. (2024). On Lasso and adaptive Lasso for non-random sample in credit scoring. Statistical Modelling, 24(2), 115-138. https://doi.org/10.1177/1471082x221092181

Prediction models in credit scoring are often formulated using available data on accepted applicants at the loan application stage. The use of this data to estimate probability of default (PD) may lead to bias due to non-random selection from the pop... Read More about On Lasso and adaptive Lasso for non-random sample in credit scoring.

Regularization and variable selection in Heckman selection model (2021)
Journal Article
Ogundimu, E. O. (2022). Regularization and variable selection in Heckman selection model. Statistical Papers, 63(2), 421-439. https://doi.org/10.1007/s00362-021-01246-z

Sample selection arises when the outcome of interest is partially observed in a study. A common challenge is the requirement for exclusion restrictions. That is, some of the covariates affecting missingness mechanism do not affect the outcome. The dr... Read More about Regularization and variable selection in Heckman selection model.

Prediction of default probability by using statistical models for rare events (2019)
Journal Article
Ogundimu, E. O. (2019). Prediction of default probability by using statistical models for rare events. Journal of the Royal Statistical Society: Series A, 182(4), 1143-1162. https://doi.org/10.1111/rssa.12467

Prediction models in credit scoring usually involve the use of data sets with highly imbalanced distributions of the event of interest (default). Logistic regression, which is widely used to estimate the probability of default, PD, often suffers from... Read More about Prediction of default probability by using statistical models for rare events.

A robust imputation method for missing responses and covariates in sample selection models (2017)
Journal Article
Ogundimu, E. O., & Collins, G. S. (2019). A robust imputation method for missing responses and covariates in sample selection models. Statistical Methods in Medical Research, 28(1), 102-116. https://doi.org/10.1177/0962280217715663

Sample selection arises when the outcome of interest is partially observed in a study. Although sophisticated statistical methods in the parametric and non-parametric framework have been proposed to solve this problem, it is yet unclear how to deal w... Read More about A robust imputation method for missing responses and covariates in sample selection models.

Predictive performance of penalized beta regression model for continuous bounded outcomes (2017)
Journal Article
Ogundimu, E. O., & Collins, G. S. (2018). Predictive performance of penalized beta regression model for continuous bounded outcomes. Journal of Applied Statistics, 45(6), 1030-1040. https://doi.org/10.1080/02664763.2017.1339024

Prediction models for continuous bounded outcomes are often developed by fitting ordinary least-square regression. However, predicted values from such method may lie outside the range of the outcome as it is bounded within a fixed range, with nonline... Read More about Predictive performance of penalized beta regression model for continuous bounded outcomes.

Quantifying the impact of different approaches for handling continuous predictors on the performance of a prognostic model (2016)
Journal Article
Collins, G. S., Ogundimu, E. O., Cook, J. A., Manach, Y. L., & Altman, D. G. (2016). Quantifying the impact of different approaches for handling continuous predictors on the performance of a prognostic model. Statistics in Medicine, 35(23), 4124-4135. https://doi.org/10.1002/sim.6986

Continuous predictors are routinely encountered when developing a prognostic model. Investigators, who are often non-statisticians, must decide how to handle continuous predictors in their models. Categorising continuous measurements into two or more... Read More about Quantifying the impact of different approaches for handling continuous predictors on the performance of a prognostic model.

A unified approach to multilevel sample selection models (2016)
Journal Article
Ogundimu, E. O., & Hutton, J. L. (2016). A unified approach to multilevel sample selection models. Communications in Statistics - Theory and Methods, 45(9), 2592-2611. https://doi.org/10.1080/03610926.2014.887108

We propose a unified approach for multilevel sample selection models using a generalized result on skew distributions arising from selection. If the underlying distributional assumption is normal, then the resulting density for the outcome is the con... Read More about A unified approach to multilevel sample selection models.

Sample size considerations for the external validation of a multivariable prognostic model: a resampling study (2015)
Journal Article
Collins, G. S., Ogundimu, E. O., & Altman, D. G. (2016). Sample size considerations for the external validation of a multivariable prognostic model: a resampling study. Statistics in Medicine, 35(2), 214-226. https://doi.org/10.1002/sim.6787

After developing a prognostic model, it is essential to evaluate the performance of the model in samples independent from those used to develop the model, which is often referred to as external validation. However, despite its importance, very little... Read More about Sample size considerations for the external validation of a multivariable prognostic model: a resampling study.

A Sample Selection Model with Skew-normal Distribution (2015)
Journal Article
Ogundimu, E. O., & Hutton, J. L. (2016). A Sample Selection Model with Skew-normal Distribution. Scandinavian Journal of Statistics, 43(1), 172-190. https://doi.org/10.1111/sjos.12171

Non-random sampling is a source of bias in empirical research. It is common for the outcomes of interest (e.g. wage distribution) to be skewed in the source population. Sometimes, the outcomes are further subjected to sample selection, which is a typ... Read More about A Sample Selection Model with Skew-normal Distribution.

On the extended two-parameter generalized skew-normal distribution (2015)
Journal Article
Ogundimu, E. O., & Hutton, J. L. (2015). On the extended two-parameter generalized skew-normal distribution. Statistics and Probability Letters, 100, 142-148. https://doi.org/10.1016/j.spl.2015.02.016

We propose a three-parameter skew-normal distribution, obtained by using hidden truncation on a skew-normal random variable. The hidden truncation framework permits direct interpretation of the model parameters. A link is established between the mode... Read More about On the extended two-parameter generalized skew-normal distribution.