Dr Will Brittain's Outputs (2)

One-pot ester and thioester formation mediated by pentafluoropyridine (PFP) (2022)
Journal Article
Beardmore, L. N., Cobb, S. L., & Brittain, W. D. (2022). One-pot ester and thioester formation mediated by pentafluoropyridine (PFP). Organic and Biomolecular Chemistry, 20(41), 8059-8064. https://doi.org/10.1039/d2ob01268e

Acyl fluorides are valuable synthetic intermediates, but in some cases they can be challenging to handle and difficult to isolate given their susceptibility to degradation. In addition, many reagents utilised to prepare acyl fluorides are incompatibl... Read More about One-pot ester and thioester formation mediated by pentafluoropyridine (PFP).

Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase (2022)
Journal Article
Wang, S., Brittain, W. D., Zhang, Q., Lu, Z., Tong, M. H., Wu, K., …Deng, H. (2022). Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase. Nature Communications, 13(1), https://doi.org/10.1038/s41467-021-27512-0

Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They consist of several multienzyme subunits that must interact with each other in a highly controlle... Read More about Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.