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Outputs (3)

Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach (2024)
Journal Article
Denny, P. (online). Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach. ACS Infectious Diseases,

The lack of effective vaccines and the development of resistance to the current treatments highlights the urgent need for new antileishmanials. Sphingolipid metabolism has been proposed as a promising source of Leishmania-specific targets as these li... Read More about Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach.

Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing (2024)
Journal Article
Koutsogiannis, Z., & Denny, P. W. (2024). Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing. AMB Express, 14(1), Article 68. https://doi.org/10.1186/s13568-024-01728-x

Toxoplasma gondii is an obligate intracellular parasite associated with severe disease, especially in the immunosuppressed. It is also a cause of congenital malformation and abortion in both animals and humans and is considered one of the most import... Read More about Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing.

Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads (2024)
Journal Article
Agostino, V. S., Buerdsell, M. L., Uliana, S. R. B., Denny, P. W., Coelho, A. C., & Steel, P. G. (2024). Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads. Organic and Biomolecular Chemistry, 22(9), 1812-1820. https://doi.org/10.1039/d3ob02091f

A library of hybrid molecules is developed based on the common chemical features shared by clemastine and tamoxifen both of which are well known for their antileishmanial activities. In the initial screening against Leishmania major and L. amazonensi... Read More about Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads.