Outputs (6)

An iPSC Patient Specific Model of CFH (Y402H) Polymorphism Displays Characteristic Features of AMD and Indicates a Beneficial Role for UV Light Exposure (2017)
Journal Article
Hallam, D., Collin, J., Bojic, S., Chichagova, V., Buskin, A., Xu, Y., …Lako, M. (2017). An iPSC Patient Specific Model of CFH (Y402H) Polymorphism Displays Characteristic Features of AMD and Indicates a Beneficial Role for UV Light Exposure. Stem Cells, 35(11), 2305-2320. https://doi.org/10.1002/stem.2708

Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatment... Read More about An iPSC Patient Specific Model of CFH (Y402H) Polymorphism Displays Characteristic Features of AMD and Indicates a Beneficial Role for UV Light Exposure.

MicroRNAs in the skin: role in development, homoeostasis and regeneration (2017)
Journal Article
Horsburgh, S., Fullard, N., Roger, M., Degnan, A., Todryk, S., Przyborski, S., & O’Reilly, S. (2017). MicroRNAs in the skin: role in development, homoeostasis and regeneration. Clinical Science, 131(15), 1923-1940. https://doi.org/10.1042/cs20170039

The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each, a tightly regulated network of molecular signals control developm... Read More about MicroRNAs in the skin: role in development, homoeostasis and regeneration.

Systems modelling ageing: from single senescent cells to simple multi-cellular models (2017)
Journal Article
Martinez Guimera, A., Welsh, C., Dalle Pezze, P., Fullard, N., Nelson, G., Roger, M., …Shanley, D. (2017). Systems modelling ageing: from single senescent cells to simple multi-cellular models. Essays in Biochemistry, 61(3), 369-377. https://doi.org/10.1042/ebc20160087

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we disc... Read More about Systems modelling ageing: from single senescent cells to simple multi-cellular models.

Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis (2017)
Journal Article
Yang, C., Xu, Y., Yu, M., Lee, D., Alharti, S., Hellen, N., …Armstrong, L. (2017). Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis. Human Molecular Genetics, 26(16), 3031-3045. https://doi.org/10.1093/hmg/ddx140

Hypoplastic left heart syndrome (HLHS) is among the most severe forms of congenital heart disease. Although the consensus view is that reduced flow through the left heart during development is a key factor in the development of the condition, the mol... Read More about Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis.

Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales (2017)
Journal Article
Haffez, H., Khatib, T., McCaffery, P., Przyborski, S., Redfern, C., & Whiting, A. (2018). Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales. Molecular Neurobiology, 55(3), 1942-1950. https://doi.org/10.1007/s12035-017-0440-7

All-trans retinoic acid (ATRA) plays key roles in neurogenesis mediated by retinoic acid receptors (RARs). RARs are important targets for the therapeutic regulation of neurogenesis but effective drug development depends on modelling-based strategies... Read More about Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales.

Advanced cell culture technology for generation of in vivo-like tissue models (2017)
Journal Article
Przyborski, S. (2017). Advanced cell culture technology for generation of in vivo-like tissue models. International journal of health animal science & food safety, 4(1), https://doi.org/10.13130/2283-3927/8524

Human tissues are mostly composed of different cell types, that are often highly organised in relation to each other. Often cells are arranged in distinct layers that enable signalling and cell-to-cell interactions. Here we describe the application o... Read More about Advanced cell culture technology for generation of in vivo-like tissue models.